한국식품영양과학회지 (Journal of the Korean Society of Food Science and Nutrition)

  • 제33권1호
  • /
  • Pages.78-82
  • /
  • 2004
  • /
  • 1226-3311(pISSN)
  • /
  • 2288-5978(eISSN)
한국식품영양과학회 (The Korean Society of Food Science and Nutrition)
권호 표지
DOI QR코드

DOI QR Code

한약재 조성물이 흰쥐의 알코올성 숙취 및 사염화탄소 유발 간 손상에 미치는 영향

Effect of an Oriental Herbal Composition, Jang Baek Union (JBU), on Alcohol-Induced Hangover and CCl4-Induced Liver Injury in Rats

  • 양동식 (한국한의학연구원 의료연구부) ;
  • 홍성길 (한국한의학연구원 의료연구부) ;
  • 최선미 (한국한의학연구원 의료연구부) ;
  • 김복남 (장백산간신약물연구소) ;
  • 성현제 (세명대학교 한의과대학) ;
  • 윤우식 (한국한의학연구원 의료연구부)
  • 발행 : 2004.01.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

본 연구에서는 숙취제거 및 간기능 개선에 전통적으로 사용되어온 한약재로 구성된 조성물 JBU의 효능을 동물실험을 통하여 검증하였다. 숙취제거 효능을 확인하기 위하여 알코올과 그 대사산물인 아세트알데히드의 혈중 농도를 측정한 결과, 혈중 알코을 농도에서 JBU 추출물 처리군은 대조군에 비해 유의적인 감소를 보였고, 특히 숙취의 원인물질로 지목되는 아세트알데히드 감소에 있어서도 유의적인 효과를 보였다. 간기능개선 효능의 확인을 위하여서는 사염화탄소 유발 간손상 동물모델에서 GPT와 GOT의 활성도를 측정하여 간손상 정도를 확인하였고, 조직병리학적 관찰을 통하여 간의 병적 변화를 관찰하였다. 사염화탄소는 확연하게 간손상을 유발시켰고, JBU 추출물은 GPT 및 GOT의 증가를 유의적으로 억제하였으며 조직학적으로도 간조직의 손상을 뚜렷하게 억제하였다.

Effects of the extract of oriental herbal composition, Jang Baek Union (JBU), on hangover and liver function were studied in rats. To investigate anti-hangover effect, alcohol concentration and acetaldehyde concentration of blood were measured after oral ethanol treatment. Blood alcohol concentration was significantly reduced by pre-treatment of JBU extract. The effect of JBU extract on the blood acetaldehyde concentration was more significant than commercial product used as a positive control. To investigate hepato-protective effect, serum GOT and GPT levels and histological changes of liver tissue were analyzed in $CCl_4$-treated rats. JBU extract adminstration significantly inhibited the increase of serum GPT and GOT levels induced by $CCl_4$-treatment. Moreover, histological injuries of liver tissue such as fatty changes and sinusoidal leukocytosis were inhibited by JBU extract.

키워드

참고문헌

  1. Alcohol Health Res World v.22 Alcohol hangover, mechanism and mediators. Swift,R.;Davidson,D.
  2. Medical and nutritional complications of alcoholism: mechanism and management. Alcohol and liver Lieber,C.S.;Leo,M.A.;Lieber.C.S.(ed.)
  3. Hepatology v.6 Alcohol and cancer Lieber,C.S.;Garro,A.;Leo,M.A;Mak,K.M.;Wornor,T. https://doi.org/10.1002/hep.1840060533
  4. The pharmarcological basis of therapeutic(5th ed.) Goodman,L.S.;Gilman,A.
  5. Progress in lever deseases Lieber,C.S.;Leo,M.A.;Popper,H.(ed.);Schaffner,F.(ed.)
  6. Acta Med Scand v.703 Alcohol and liver: metabolism of ethanol, metabolic effects and pathogenesis of injury Lieber,C.S.
  7. Science v.162 Ethanol oxidation by hepatic microsomes: adaptive increase after ethanol feeding. Lieber,C.S.;DeCarli,L.M. https://doi.org/10.1126/science.162.3856.917
  8. Herbology(1st ed.) Lee,S.I.
  9. Clin Chem v.28 Evaluation of a modified alcohol dehydrogenase assay for the determination of ethanol in blood. Poklis,A.;Mackell,M.A.
  10. Clin Chem v.33 Gas-chromatographic determination of ethanol in blood with 0.53mm fused-silica open tubular columns. Penton,Z.
  11. Amer J Clin Pathol v.28 A colorimetric method for the determination of serum glutamic oxaloacetic and pyruvic transaminase. Reitman,S.;Frankel,S.
  12. Gastroenterology v.84 Alcoholic foamy degeneration: a pattern of acute alcoholic injury of the liver. Uchida,T.;Kao,H.;Zuispe-Sjogen M.;Peters,R.L.
  13. Food Indus Nutr v.4 Cause and effect of hangover. Kim,C.I.
  14. J Forensic Med v.14 A study of the metabolism rates of alcohol in the human body. Shumate,R.P.;Crowther,R.F.;Zaraafshan,H.
  15. N Eng J Med v.288 Liver adaptation and injury in alcoholism. Lieber,C.S. https://doi.org/10.1056/NEJM197302152880710
  16. Kor Ind Hyg Assoc J v.4 Activity of alcohol dehydrogenase and ethanol, acetaldehyde levels in normal adults blood. Kim,K.W.;Yang,J.S.;Lee,J.S.;Cho,Y.S.;Kang,S.K.;Chung,H.K.
  17. Alcohol Clin Exp Res v.12 Effect of acute ethanol administration on human blood aldehyde dehydrogenase activity. Helander,A.;Tottmar,O. https://doi.org/10.1111/j.1530-0277.1988.tb00257.x
  18. Lab Invest v.47 Biology of disease: free radicals and tissue injury. Freeman,B.A.;Crapo,J.D.
  19. J Biol Chem v.266 Hydrogen peroxide causes the fatal injury to human fibroblasts exposed to oxygen radicals. Simon,R.H.;Scoggin,C.M.;Patterson,D.
  20. J Applied Pharm v.10 Protective effects of Angelica tenuissima Nakai on hepatotoxicity by carbon tetrachloride in rats. Jeong,C.S.;Jung,K.H. https://doi.org/10.4062/biomolther.2002.10.4.211
  21. Principles and methods of toxicology Hays,A.W.

피인용 문헌

  1. Alcohol metabolizing and antioxidant activities of complex herbal extracts from medicinal plants vol.20, pp.5, 2011, https://doi.org/10.1007/s10068-011-0184-5
  2. Effect of Herbal Composition on Alcohol Degradation and Anti-inflammatory Activity in Mice vol.24, pp.4, 2011, https://doi.org/10.9799/ksfan.2011.24.4.489
  3. Effect of Herbal Composition, DTS20 on Alcohol Degradation and Anti-inflammatory Activity vol.26, pp.5, 2011, https://doi.org/10.7841/ksbbj.2011.26.5.433
  4. Effects of the herb mixture, DTS20, on oxidative stress and plasma alcoholic metabolites after alcohol consumption in healthy young men vol.5, pp.4, 2016, https://doi.org/10.1016/j.imr.2015.10.001
  5. Hangover Relieving through Algae and Plant Complex Extract using Lava Sea Water vol.22, pp.2, 2018, https://doi.org/10.13050/foodengprog.2018.22.2.110
  6. 헛개나무 열매를 주성분으로 제조한 새로운 처방이 알코올 분해 및 간 손상에 미치는 영향 vol.35, pp.7, 2004, https://doi.org/10.3746/jkfn.2006.35.7.828
  7. Hepatoprotective and Anti-fatigue Effects of Lactic Acid Bacteria (Lactobacillus acidophilus, Bifidobacterium bifidum and Streptococcus thermophilus) vol.23, pp.1, 2004, https://doi.org/10.5487/tr.2007.23.1.011
  8. 마늘과 한약재 추출물의 혼합급이가 알코올 투여에 의한 간기능 및 지질대사에 미치는 영향 vol.38, pp.5, 2009, https://doi.org/10.3746/jkfn.2009.38.5.561
  9. 건강한 남자 대학생에서 민들레즙 보충이 알코올에 의한 산화적 스트레스 및 숙취에 미치는 효과 vol.38, pp.6, 2004, https://doi.org/10.3746/jkfn.2009.38.6.683
  10. 단기 알코올 투여 시 마늘과 한약재 복합물이 체내 지질 조성 및 간기능 회복에 미치는 영향 vol.19, pp.7, 2009, https://doi.org/10.5352/jls.2009.19.7.934
  11. 한약제 추출물로 제조된 식혜가 고지방식이에 의한 흰주의 간 손상과 간 지질 함량에 미치는 영향 vol.19, pp.8, 2009, https://doi.org/10.5352/jls.2009.19.8.1104