Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Cytotoxic and Antibacterial Activities of Sanguisorbae officinalis L.

지유(地楡)(Sanguisorbae officinalis L.)의 항암 및 항균효과

  • Lee, Soon-Ae (Department of Cosmetic Engineering, Daegu Haany University) ;
  • Son, Jun-Ho (Department of Cosmetic Engineering, Daegu Haany University) ;
  • Kwak, Jae-Hoon (Department of Cosmetic Engineering, Daegu Haany University) ;
  • Park, Jung-Mi (Department of Cosmetic Engineering, Daegu Haany University) ;
  • Lee, Jin-Young (Department of Cosmetic Engineering, Daegu Haany University) ;
  • An, Bong-Jeun (Department of Cosmetic Engineering, Daegu Haany University)
  • 이순애 (대구한의대학교 화장품공학과) ;
  • 손준호 (대구한의대학교 화장품공학과) ;
  • 곽재훈 (대구한의대학교 화장품공학과) ;
  • 박정미 (대구한의대학교 화장품공학과) ;
  • 이진영 (대구한의대학교 화장품공학과) ;
  • 안봉전 (대구한의대학교 화장품공학과)
  • Published : 2004.03.31
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Abstract

The cytotoxic and antibacterial activities of Sanguisorbae officinalis L., which is known as a major tannin source, were investigated to check the possible use of natural nutraceutics or cosmetics. The S. officinalis inhibited cancer cell growth in a dose-dependant manner. Also, the clear zone against various bacteria such as Staphylococcus aureus, S. epidermidis, E. coli were evident at 0.5 and 1 mg/disc. When the concentrations were 500 and 1,000 ppm, growth of all aerobic bacteria increased at early stage but decrease afterward. The results indicated that S. officinalis had the anti-skin cancer activity as well as antibacterial activity against skin-related bacteria.

본 연구에서는 탄닌성분을 다량 함유하고 있는 장미과 식물 지유의 생리활성기능을 살펴 식품 및 화장품산업의 천연소재로서의 활용가능성을 검토하였다. 각종 암세포에 대한 세포증식 억제율은 시료 농도가 증가함에 따라 유의적으로 증가하였고, Staphylococcus aureus, S. epidermidis, E. coli와 같은 세균에 대한 clear zone 형성을 관찰한 결과 추출물 0.5 mg/disc, 1 mg/disc의 농도에서 모든균에서 clear zone형성을 관찰할 수 있었으며, 생균수측정의 결과 500 ppm및 1,000 ppm에서 균수가 서서히 증가한 후 감소하였다.

Keywords

References

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