Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Anti-tumor activity of Korean Oldenlandiae Herba and Radix

국내산 백화사설초 전초와 뿌리의 항암효과

  • Lee, Hyo-Jeong (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Lee, Eun-Ok (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Rhee, Yun-Hee (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Kim, Kwan-Hyun (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Lee, Jae-Ho (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Baek, Nam-In (School of Biotechnology and Plant Metabolism Research Center, KyungHee University) ;
  • Ra, Jeong-Chan (RNL Life Science Ltd.) ;
  • Kim, Sung-Hoon (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
  • 이효정 (경희대학교 동서의학 대학원 종양학 실험실) ;
  • 이은옥 (경희대학교 동서의학 대학원 종양학 실험실) ;
  • 이연희 (경희대학교 동서의학 대학원 종양학 실험실) ;
  • 김관현 (경희대학교 동서의학 대학원 종양학 실험실) ;
  • 이재호 (경희대학교 동서의학 대학원 종양학 실험실) ;
  • 백남인 (경희대학교 생명공학연구원) ;
  • 나정찬 (RNL생명과학(주)) ;
  • 김성훈 (경희대학교 동서의학 대학원 종양학 실험실)
  • Published : 2004.06.30
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Abstract

For the evaluation of anti-tumor activity of Korean Oldenlandia Herb (KOH) and Radix (KOR), our experiment was performed with methanol extracts of KOH and KOR. They did not shown any cytotoxicity against HT1080 cell lines. However, they effectively showed anti-metastatic activity through inhibition of the adhesion of HT1080 cells to gelatin, downregulated the expression of MMP2 and uPA and upregulated the expression of TIMP2. They also inhibited tube formation of HUVECs induced by bFGF. However, they did not affect DNA topoisomerase I activity. Simiarly, the T/Cs % in KOH and KOR treated mice were increased 134.9% and 171 %, respectively at 2500 mg/kg. These results suggest that KOH and KOR exert anti-tumor activity via anti-metastatic and anti-angiogenic activities. The further study for isolation of effective compounds and its exact mechanism and comparative study with Chinese Oldenlandia Herba will be required.

Keywords

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