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Anti-tumor activity of Korean Oldenlandiae Herba and Radix  

Lee, Hyo-Jeong (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Lee, Eun-Ok (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Rhee, Yun-Hee (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Kim, Kwan-Hyun (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Lee, Jae-Ho (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Baek, Nam-In (School of Biotechnology and Plant Metabolism Research Center, KyungHee University)
Ra, Jeong-Chan (RNL Life Science Ltd.)
Kim, Sung-Hoon (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Publication Information
Korean Journal of Pharmacognosy / v.35, no.2, 2004 , pp. 110-115 More about this Journal
Abstract
For the evaluation of anti-tumor activity of Korean Oldenlandia Herb (KOH) and Radix (KOR), our experiment was performed with methanol extracts of KOH and KOR. They did not shown any cytotoxicity against HT1080 cell lines. However, they effectively showed anti-metastatic activity through inhibition of the adhesion of HT1080 cells to gelatin, downregulated the expression of MMP2 and uPA and upregulated the expression of TIMP2. They also inhibited tube formation of HUVECs induced by bFGF. However, they did not affect DNA topoisomerase I activity. Simiarly, the T/Cs % in KOH and KOR treated mice were increased 134.9% and 171 %, respectively at 2500 mg/kg. These results suggest that KOH and KOR exert anti-tumor activity via anti-metastatic and anti-angiogenic activities. The further study for isolation of effective compounds and its exact mechanism and comparative study with Chinese Oldenlandia Herba will be required.
Keywords
Korean; Oldenlandia diffusa; Herba; Radix; anti-tumor; adhesion; tube formation; uPA; MMP2; TIMP2; S-180;
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