Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Anti-inflammatory and Antinociceptive Activities of 'Coccinia indica W. &A.' Fruit Juice Powder in Animals

  • Rao, GMM (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute) ;
  • Rao, Ch V (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute) ;
  • Sudhakara, M. (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute) ;
  • Pandey, M M (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute) ;
  • Rawat, AKS (Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute) ;
  • Sirwaikar, A (Department of Pharmacognosy, College of Pharmaceutical Sciences) ;
  • Joshi, AB (Department of Pharmacognosy, NGSM Institute of Pharmaceutical Sciences)
  • Published : 2004.02.28
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Abstract

The fresh fruit juice powder of Coccinia indica W.&A., (Cucurbitaceae, CJP) was studied for the possible activities of antiinflammatory and antinociceptive to rationalize the folkloric use of the plant juice as rasayana. CJP at the doses of 50-200 mg/kg caused a significant (P<0.05 to P<0.001) inhibition of paw edema induced by ${\lambda}$ carrageenin (1%) and histamine $(10^{-3}\;g/ml,\;0.1\;ml)$ in rats. The effect was comparable to the standard cycloxygenase inhibitor brufen at 100 mg/kg and protective percentages were 63.41% and 65.78% respectively. Administration of CJP (50-200 mg/kg) exhibited a moderate increase of the pain threshold on analgesy-meter induced mechanical pain. However CJP significantly prevented the writhing induced by acetic acid in mice and the percentages of inhibitions were 16.98%-35.47%, which is equivalent to 36.67% produced by brufen. These data indicate that the fruit juice of Coccinia indica rationalizes the traditional system of medicine.

Keywords

References

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