The Korean Journal of Physiology and Pharmacology

  • 제8권4호
  • /
  • Pages.173-179
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  • 2004
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  • 1226-4512(pISSN)
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  • 2093-3827(eISSN)
대한약리학회 (The Korean Society of Pharmacology)
권호 표지

The Role of BF-7 on Neuroprotection and Enhancement of Cognitive Function

  • Chae, Hee-Sun (Department of Anatomy, College of Medicine, Chung-Ang University) ;
  • Kang, Yong-Koo (Biogrand Inc., Chung-Ang University) ;
  • Shin, Yong-Kyu (Department of Pharmacology, College of Medicine, Chung-Ang University) ;
  • Lee, Hyun-Jung (Department of Anatomy, College of Medicine, Chung-Ang University) ;
  • Yu, Ji-In (Department of Anatomy, College of Medicine, Chung-Ang University) ;
  • Lee, Kwang-Gill (Department of Sericultural and Entomology, National Institute of Agriculture Science Technology, RDA) ;
  • Yeo, Joo-Hong (Department of Sericultural and Entomology, National Institute of Agriculture Science Technology, RDA) ;
  • Kim, Yong-Sik (Departments of Pharmacology, Seoul Municipal Boramae Hospital, College of Medicine, Seoul National University) ;
  • Sohn, Dong-Suep (Departments of Thoracic & Cardiovascular Medicine, College of Medicine, Chung-Ang University) ;
  • Kim, Kyung-Yong (Department of Anatomy, College of Medicine, Chung-Ang University) ;
  • Lee, Won-Bok (Department of Anatomy, College of Medicine, Chung-Ang University) ;
  • Lee, Sang-Hyung (Departments of Neurosurgery, Seoul Municipal Boramae Hospital, College of Medicine, Seoul National University) ;
  • Kim, Sung-Su (Departments of Anatomy, College of Medicine, Biogrand Inc., Chung-Ang University)
  • 발행 : 2004.08.21
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초록

Amyloid ${\beta}-peptide\;(A{\beta})$ contributes to the pathogenesis of Alzheimer's disease (AD), causing neuronal death through apoptosis. In this study, the neuroprotective role of BF-7, extracted form sericultural product, was examined against $A{\beta}-induced$ toxicity in cultured human neuronal cell SKN-SH. In order to know if the BF-7 has positive role on the cognition and memory in human, the mixture of BF-7, DHA and EPA (BDE) was examined using Rey Kim and K-WAIS test with 50 healthy high school student. We report here that BDE significantly attenuated $A{\beta}-induced$ apoptosis through the reduction of ROS accumulation, and diminished caspase-like protease activity. Moreover, the memory index and memory preservation, and attentative concentration of BDE treated group for 1 month were significantly improved, in contrast to the case of placebo control treated with DHA and EPA. This result represent that the BF-7 play significant positive role on learning memory. Taken together, our result suggested the natural product BF-7 is a good substance for the brain functionally and physiologically.

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참고문헌

  1. Behl C, Davis J, Cole GM, Schubert D. Vitamin E protects nerve cells from amyloid toxicity. Biochem. Biophys Res Commun 186: 944-950, 1992 https://doi.org/10.1016/0006-291X(92)90837-B
  2. Boland B, Campbell V. beta-Amyloid (1-40)-induced apoptosis of cultured cortical neurones involves calpain-mediated cleavage of poly-ADP-ribose polymerase. Neurobiol Aging 24: 179-186, 2003 https://doi.org/10.1016/S0197-4580(02)00060-X
  3. Cutler RG, Kelly J, Storie K, Pedersen WA, Tammara A, Hatanpaa K, Troncoso JC, Mattson MP. Involvement of oxidative stressinduced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proc Natl Acad Sci USA 101: 2070-2075, 2004 https://doi.org/10.1073/pnas.0305799101
  4. Cummings JL, Kaufer D. Neuropsychiatric aspects of Alzheimer's disease: the cholinergic hypothesis revisited. Neurology 47: 876 -883, 1996 https://doi.org/10.1212/WNL.47.4.876
  5. Goodman YD, Mattson MP. Staurosporin and K-252 compounds protect hippocampal neurons against amyloid $\beta$-peptide toxicity and oxidative injury. Brain Res 650: 170-174, 1994 https://doi.org/10.1016/0006-8993(94)90223-2
  6. Guo ZH, Mattson MP. Neurotrophic factors protect terminals against amyloid- and oxidative stress-induced impairment of glucose transport, glutamate transport and mitochondrial function. Cereb Cortex 10: 50-57, 2000 https://doi.org/10.1093/cercor/10.1.50
  7. Kumar U, Dunlop DM, Richardson JS. The acute neurotoxic effect of $\beta$-amyloid on mature cultures of rat hippocampal neurons is attenuated by the anti-oxidant U-78517F. Int J Neurosci 79: 185-190, 1994 https://doi.org/10.3109/00207459408986079
  8. Mattson MP. Cellular actions of $\beta$-amyloid precursor protein and its soluble and fibrillogenic derivates. Physiol Rev 77: 1081- 1132, 1997
  9. Min SK, Moon IW, Ko RW, Shin HS. Effects of transdermal nicotine on attention and memory in healthy elderly non-smokers. Psychopharmacology (Berl) 159: 83-88, 2001 https://doi.org/10.1007/s002130100899
  10. Permanne B, Adessi C, Saborio GPSF, Frossard MJ. Van Dopre J, Dewachter I, Banks WA, Van Leuven F, Soto C. Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a $\beta$-sheet breaker peptide. FASEB J 16: 860-862, 2002
  11. Shimoke K, Chiba H. Nerve growth factor prevents 1-methyl-4- penyl-1,2,3,6- tetrahydropyridine-induced cell death via the Akt athway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease. J Neurosci Res 63: 402-409, 2001 https://doi.org/10.1002/1097-4547(20010301)63:5<402::AID-JNR1035>3.0.CO;2-F
  12. Soreghan B, Thomas SN, Yang AJ. Aberrant sphingomyelin/ ceramide metabolic- induced neuronal endosomal/lysosomal dysfunction: potential pathological consequences in age-related neurodegeneration. Adv Drug Deliv Rev 55: 1515-1524, 2003 https://doi.org/10.1016/j.addr.2003.07.007
  13. Soto C, Sigurdsson EM, Morelli L, Kumar RA, Castano EM, Frangione B. $\beta$-Sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy. Nat Med 4: 822-826, 1998 https://doi.org/10.1038/nm0798-822
  14. Uauy-Dagach R, Valenzuela A. Marine oils as a source of omega-3 fatty acids in the diet: how to optimize the health benefits. Prog Food Nutr Sci 16:199-243, 1992
  15. Wang JY, Shum AY, Ho YJ, Wang JY. Oxidative neurotoxicity inrat cerebral cortex neurons: synergistic effects of H2O2 and NO on apoptosis involving activation of p38 mitogen-activated protein kinase and caspase-3. J Neurosci Res 72: 508-519, 2003 https://doi.org/10.1002/jnr.10597
  16. Weiss JH, Turetsky D, Wilke G, Choi DW. AMPA/kainate receptormediated mage to NADPH-diaphorase containing neurons is Ca2$^+$ dependant. Neurosci Lett 167: 93-96, 1994 https://doi.org/10.1016/0304-3940(94)91035-9
  17. Yakovlev AG, Faden AI. Caspase-dependent apoptotic pathways in CNS injury. Mol Neurobiol 24: 131-144, 2001 https://doi.org/10.1385/MN:24:1-3:131
  18. Yankner BA. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 16: 921-932, 1996 https://doi.org/10.1016/S0896-6273(00)80115-4