In vitro Antimalarial Effect of Bamboo Family Aganist P. falciparum

열대열 말라리아에 대한 상피목 및 죽과의 항 말라리아의 효과

  • Park Hyun (Department of Parasitology, College of Medicine, Wonkwang University) ;
  • Kim Myung Soo (Life Scienceces Division, Korea Institute of Science and Technology) ;
  • Jeon Byung Hun (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Lee John Hwa (College of Veterinary Medicine, Chonbuk National University) ;
  • Takaya Yoshiaki (Faculty of Pharmacy, Meijo University) ;
  • Wataya Yusuke (Faculty of Pharmaceutical Sciences, Okayama University) ;
  • Kim Hye Sook (Faculty of Pharmaceutical Sciences, Okayama University)
  • 박현 (원광대학교 의과대학 기생충학교실) ;
  • 김명수 (한국과학기술 연구원 생체과학부) ;
  • 전병훈 (원광대학교 한의과대학 병리학교실) ;
  • 이존화 (전북대학교 수의과대학 공중보건학실) ;
  • ;
  • ;
  • 김혜숙 (오까야마대학교 약학대학 의약품 정보학교실)
  • Published : 2003.06.01

Abstract

Among extracts prepared from Alstonia scholaris, Phyllostachys pubescens and Bambusa veitchii, methanol fraction of Alstonia scholaris was found to have antiplasmodial effect by inhibiting growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with less than 14 μg/ml of EC50 values. Methanol fraction 2 of Alstonia scholaris revealed the strongest anti plasmodial effect with 40 μg/ml of EC50 value. Especially, this fraction showed higher than 3-folds selective toxicity on a Plasmodium as the EC value was 116 μg/ml on the host FM3A cell. This is the first report on which an extract compound from Alstonia scholaris showed antimalarial effect.

Keywords

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