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In vitro Antimalarial Effect of Bamboo Family Aganist P. falciparum  

Park Hyun (Department of Parasitology, College of Medicine, Wonkwang University)
Kim Myung Soo (Life Scienceces Division, Korea Institute of Science and Technology)
Jeon Byung Hun (Department of Pathology, College of Oriental Medicine, Wonkwang University)
Lee John Hwa (College of Veterinary Medicine, Chonbuk National University)
Takaya Yoshiaki (Faculty of Pharmacy, Meijo University)
Wataya Yusuke (Faculty of Pharmaceutical Sciences, Okayama University)
Kim Hye Sook (Faculty of Pharmaceutical Sciences, Okayama University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.3, 2003 , pp. 777-779 More about this Journal
Abstract
Among extracts prepared from Alstonia scholaris, Phyllostachys pubescens and Bambusa veitchii, methanol fraction of Alstonia scholaris was found to have antiplasmodial effect by inhibiting growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with less than 14 μg/ml of EC50 values. Methanol fraction 2 of Alstonia scholaris revealed the strongest anti plasmodial effect with 40 μg/ml of EC50 value. Especially, this fraction showed higher than 3-folds selective toxicity on a Plasmodium as the EC value was 116 μg/ml on the host FM3A cell. This is the first report on which an extract compound from Alstonia scholaris showed antimalarial effect.
Keywords
Plasmodium falciparum; Alstonia scholaris; antiplasmodial effect;
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