Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Rubus coreanus Miquel on the Specific Immune Response in Mice

복분자가 생쥐의 특이적 면역반응에 미치는 영향

  • Won Kyung Sook (Department of College of pharmacy, Woosuk University) ;
  • Lee Tae Won (Department of College of pharmacy, Woosuk University) ;
  • Eun Jae Soon (Department of College of pharmacy, Woosuk University) ;
  • Song Jung Mo (College of Oriental Medicine, Woosuk University)
  • Published : 2003.06.01
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Abstract

The specific immune response of unripened fruits and ripened fruits of Rubus coreanus Miquel was examined in BALB/C mice. The 70% ethyl alcohol extracts (20 or 100 mg/kg) of unripened fruits (RCE-I) and of ripened fruits (RCE-II) were administered p.o. once a day for 7 days. RCE-I and RCE-II decreased the viability of thymocytes, but increased the viability of splenocytes. Also, RCE-I enhanced the population of helper T and cytotoxic T cells in thymocytes and RCE-II enhanced the population of helper T cells. Furthermore, RCE-I and RCE-II decreased the population of B220/sup +/ cells and Thy1/sup +/ cells and helper T cells in splenocytes. In a general way, the immunosuppressive action of RCE-I was more potent than those of RCE-II. These results suggest that RCE-I and RCE-II have a regulative action of immune response via decrease the viability of thymocytes and increase the viability of splenocytes.

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