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Effect of Rubus coreanus Miquel on the Specific Immune Response in Mice  

Won Kyung Sook (Department of College of pharmacy, Woosuk University)
Lee Tae Won (Department of College of pharmacy, Woosuk University)
Eun Jae Soon (Department of College of pharmacy, Woosuk University)
Song Jung Mo (College of Oriental Medicine, Woosuk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.3, 2003 , pp. 656-661 More about this Journal
Abstract
The specific immune response of unripened fruits and ripened fruits of Rubus coreanus Miquel was examined in BALB/C mice. The 70% ethyl alcohol extracts (20 or 100 mg/kg) of unripened fruits (RCE-I) and of ripened fruits (RCE-II) were administered p.o. once a day for 7 days. RCE-I and RCE-II decreased the viability of thymocytes, but increased the viability of splenocytes. Also, RCE-I enhanced the population of helper T and cytotoxic T cells in thymocytes and RCE-II enhanced the population of helper T cells. Furthermore, RCE-I and RCE-II decreased the population of B220/sup +/ cells and Thy1/sup +/ cells and helper T cells in splenocytes. In a general way, the immunosuppressive action of RCE-I was more potent than those of RCE-II. These results suggest that RCE-I and RCE-II have a regulative action of immune response via decrease the viability of thymocytes and increase the viability of splenocytes.
Keywords
Rubus coreanus Miquel; thymocyte; splenocyte;
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