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The Pharmaceutical Society of Korea (대한약학회)
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Effects of a New Neuroprotective Agent KR-31378 on Liver Cytochrome P450s in Male Sprague Dawley Rats

  • Jeong, Tae-Cheon (College of Pharmacy, Yeungnam University) ;
  • Kim, Ji-Young (College of Pharmacy, Yeungnam University) ;
  • Ji, Hye-Young (College of Pharmacy, Wonkwang University) ;
  • Lee, Dong-Ha (AgroPharma Research Institute, Dongbu Hannong Chemical Co.) ;
  • Kim, Sun-Ok (AgroPharma Research Institute, Dongbu Hannong Chemical Co.) ;
  • Lim, Hong (AgroPharma Research Institute, Dongbu Hannong Chemical Co.) ;
  • Yoo, Sung-Eun (Korea Research Institute of Chemical Technology) ;
  • Lee, Hye-Suk (College of Pharmacy, Wonkwang University)
  • Published : 2003.10.01
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Abstract

The effects of KR-31378, a neuroprotective agent for ischemia-reperfusion damage, on liver microsomal cytochrome P450s (CYPs) were investigated in male Sprague Dawley rats. When rats were treated orally with KR-31378 for 7 consecutive days, CYP3A-selective erythromycin N-demethylase (ERDM) activity was significantly induced in a dose-dependent manner. In Western immunoblotting, CYP 3A proteins were clearly induced by treatment with KR-31378. Within 24 h after treatment with 80 mg/kg of KR-31378, ERDM activity was induced in liver microsomes in accompanied by induction of the level of CYP 3A proteins. The present results suggest that KR-31378 might modulate the expression of CYP 3A enzymes in humans.

Keywords

References

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