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Effects of a New Neuroprotective Agent KR-31378 on Liver Cytochrome P450s in Male Sprague Dawley Rats  

Jeong, Tae-Cheon (College of Pharmacy, Yeungnam University)
Kim, Ji-Young (College of Pharmacy, Yeungnam University)
Ji, Hye-Young (College of Pharmacy, Wonkwang University)
Lee, Dong-Ha (AgroPharma Research Institute, Dongbu Hannong Chemical Co.)
Kim, Sun-Ok (AgroPharma Research Institute, Dongbu Hannong Chemical Co.)
Lim, Hong (AgroPharma Research Institute, Dongbu Hannong Chemical Co.)
Yoo, Sung-Eun (Korea Research Institute of Chemical Technology)
Lee, Hye-Suk (College of Pharmacy, Wonkwang University)
Publication Information
Archives of Pharmacal Research / v.26, no.10, 2003 , pp. 800-804 More about this Journal
Abstract
The effects of KR-31378, a neuroprotective agent for ischemia-reperfusion damage, on liver microsomal cytochrome P450s (CYPs) were investigated in male Sprague Dawley rats. When rats were treated orally with KR-31378 for 7 consecutive days, CYP3A-selective erythromycin N-demethylase (ERDM) activity was significantly induced in a dose-dependent manner. In Western immunoblotting, CYP 3A proteins were clearly induced by treatment with KR-31378. Within 24 h after treatment with 80 mg/kg of KR-31378, ERDM activity was induced in liver microsomes in accompanied by induction of the level of CYP 3A proteins. The present results suggest that KR-31378 might modulate the expression of CYP 3A enzymes in humans.
Keywords
Induction; Cytochrome P450; KR-31378; Rat; In vivo;
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1 Blank, J. A., Tucker, A. N., Sweatlock, J., Gasiewicz, T. A., and Luster, M. I., $\alpha$-Naphthoflavone antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin induced murine ethoxyresorufin O-deethylase activity and immunosuppression. Mol. Pharmacol., 32, 168-172 (1987)
2 Jeong, T. C., Gu, H. K., Chun, Y. J., Yun, C. H., Han, S. S., and Roh, J. K., Effects of $\beta$-ionone on the expression of cytochrome P450s and NADPH-cytochrome P450 reductase in Sprague Dawley rats. Chem. Biol. Interact., 114, 97-107 (1998)   DOI   ScienceOn
3 Kim, D. H., Kim, E. J., Han, S. S., Roh, J. K., Jeong, T. C., and Park, J. H., Inhibitory effects of $H_2$-receptor antagonists on cytochrome P450s in male ICR mice. Human Exp. Toxicol., 14, 623-629 (1995)   DOI   ScienceOn
4 Kim, K. Y., Kim, B. G., Kim, S. O., Yoo, S. E., Kwak, Y. G., Chae, S. W., and Hong, K. W., Prevention of lipopolysaccharideinduced apoptosis by (2S,3S,4R)-N'-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine, a benzopyran analog, in endothelial cells. J. Pharmacol. Exp. Ther., 300, 535-542 (2002)   DOI   ScienceOn
5 Lubet, R. A., Meyer, R. T., Cameron, J. W., Nims, R. W., Burke, M. D., Wolff, J., and Guengerich, F. P., Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat. Arch. Biochem. Biophy., 238, 43-48 (1985)   DOI   ScienceOn
6 Hong, K.W., Kim, K.Y., Lee, J. H., Shin, H. K., Kwak, Y. G., Kim, S. O., Lim, H., and Yoo, S. E., Neuroprotective effect of (2S,3S,4R)-N''-cyano-N-(6-amino-3, 4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine (KR-31378), a benzopyran analog, against focal ischemic brain damage in rats. J. Pharmacol. Exp. Ther., 301, 210-216 (2002)   DOI   ScienceOn
7 Bradford, M. M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the proteindye binding. Anal. Biochem., 72, 248-254 (1976)   DOI   PUBMED   ScienceOn
8 Yoo, S. E., Yi, K. Y., Lee, S., Suh, J., Kim, N., Lee, B. H., Seo, H. W., Kim, S. O., Lee, D. H., Lim, H., and Shin, H. S., A novel anti-ischemic ATP-sensitive potassium channel opener without vasorelaxation: N-(6-aminobenzopyranyl)-N'-benzyl-N''-cyanoguanidine analogue. J. Med. Chem., 44, 4207-4215 (2001)   DOI   ScienceOn
9 Guengerich, F. P. and Kim, D. H., Enzymatic oxidation of ethyl carbamate to vinyl carbamate and its role as an intermediate in the formation of 1,$N^6$-ethenoadenosine. Chem. Res. Toxicol., 4, 413-421 (1991)   DOI   ScienceOn
10 Kim, H. J., Kim, S. H., Kim, S.-O., Lee, D.-H., Lim, H., Yoo, S. E., and Lee, M. G., Dose-dependent pharmacokinetics of a new neuroprotective agent for ischemia-reperfusion damage, KR-31378, in rats. Biopharm. Drug Dispos., 21, 279-284 (2000)   DOI   ScienceOn
11 Wrighton, S. A. and Stevens, J. C., The human hepatic cytochrome P-450s involved in drug metabolism. Crit. Rev. Toxicol., 22, 1-21 (1992)   DOI   ScienceOn
12 Nash, T., The colorimetrical estimation of formaldehyde by means of the Hantzsch reaction. Biochem. J., 55, 416-421 (1953)   DOI   PUBMED