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The Pharmaceutical Society of Korea (대한약학회)
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Gram-Positive Bacteria Specific Properties of Silybin Derived from Silybum marianum

  • Lee, Dong-Gun (School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University) ;
  • Kim, Hyung-Keun (Research Center for Proteineous Materials, Chosun University) ;
  • Park, Yoon-Kyung (Research Center for Proteineous Materials, Chosun University) ;
  • Park, Seong-Cheol (Research Center for Proteineous Materials, Chosun University) ;
  • Woo, Eun-Rhan (Research Center for Proteineous Materials, Chosun University, College of Pharmacy, Chosun University) ;
  • Jeong, Hye-Gwang (Research Center for Proteineous Materials, Chosun University, College of Pharmacy, Chosun University) ;
  • Hahm, Kyung-Soo (Research Center for Proteineous Materials, Chosun University)
  • Published : 2003.08.01
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Abstract

Silybin has a potent antibacterial activity, more potent than silymarin II, against gram-positive bacteria without hemolytic activity, whereas it has no antimicrobial activity against gram-negative bacteria or fungi. The mode of action of silybin against the gram-positive bacterial cell was examined by investigating the change in plasma membrane dynamics of bacterial cells using 1 ,6-diphenyl-1,3,5-hextriene (DPH) as a membrane probe and by assessing the inhibition of macromolecular synthesis using radiolabeled incorporation assay. The results showed that silybin inhibited RNA and protein synthesis on gram-positive bacteria.

Keywords

References

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