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Gram-Positive Bacteria Specific Properties of Silybin Derived from Silybum marianum  

Lee, Dong-Gun (School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University)
Kim, Hyung-Keun (Research Center for Proteineous Materials, Chosun University)
Park, Yoon-Kyung (Research Center for Proteineous Materials, Chosun University)
Park, Seong-Cheol (Research Center for Proteineous Materials, Chosun University)
Woo, Eun-Rhan (Research Center for Proteineous Materials, Chosun University, College of Pharmacy, Chosun University)
Jeong, Hye-Gwang (Research Center for Proteineous Materials, Chosun University, College of Pharmacy, Chosun University)
Hahm, Kyung-Soo (Research Center for Proteineous Materials, Chosun University)
Publication Information
Archives of Pharmacal Research / v.26, no.8, 2003 , pp. 597-600 More about this Journal
Abstract
Silybin has a potent antibacterial activity, more potent than silymarin II, against gram-positive bacteria without hemolytic activity, whereas it has no antimicrobial activity against gram-negative bacteria or fungi. The mode of action of silybin against the gram-positive bacterial cell was examined by investigating the change in plasma membrane dynamics of bacterial cells using 1 ,6-diphenyl-1,3,5-hextriene (DPH) as a membrane probe and by assessing the inhibition of macromolecular synthesis using radiolabeled incorporation assay. The results showed that silybin inhibited RNA and protein synthesis on gram-positive bacteria.
Keywords
Silybin; Gram-positive bacteria; 1,6-Diphenyl-1,3,5-hextriene (DPH);
Citations & Related Records

Times Cited By Web Of Science : 8  (Related Records In Web of Science)
Times Cited By SCOPUS : 9
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