Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Bioactive Prenylated Flavonoids from the Stem Bark of Artocarpus kemando

  • Seo, Eun-Kyoung (Chemistry and Life Sciences, Research Triangle Institute, College of Pharmacy, Ewha Womans University) ;
  • Lee, Dong-Ho (Chemistry and Life Sciences, Research Triangle Institute) ;
  • Shin, Young-Geun (Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois) ;
  • Chai, Hee-Byung (Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois) ;
  • Navarro, Hernan-A. (Chemistry and Life Sciences, Research Triangle Institute) ;
  • Kardono, Leonardus B.S. (Research Center for Chemistry, Indonesian Institute of Science) ;
  • Wani, Mansukh, C. (Chemistry and Life Sciences, Research Triangle Institute, College of Pharmacy, Ewha Womans University) ;
  • Rahman, Ismail (Herbarium Bogoriense, Research Center for Bilogy, Indonesian Institute of Science) ;
  • Cordell, Geoffrey-A. (Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illionois) ;
  • Farnsworth, Narman-R. (Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illionois) ;
  • Pezzuto, John-M. (Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illionois) ;
  • Kinghorn, A.-Douglas (Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illionois) ;
  • Wani, Mansukh-C. (Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illionois) ;
  • Wall, Monroe-E. (Chemistry and Life Sciences, Research Triangle Institute, College of Pharmacy, Ewha Womans University)
  • Published : 2003.02.01
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Abstract

Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassayguided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic.

Keywords

References

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