• Title/Summary/Keyword: Artocarpus kemando

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Bioactive Prenylated Flavonoids from the Stem Bark of Artocarpus kemando

  • Seo, Eun-Kyoung;Lee, Dong-Ho;Shin, Young-Geun;Chai, Hee-Byung;Navarro, Hernan-A.;Kardono, Leonardus B.S.;Wani, Mansukh, C.;Rahman, Ismail;Cordell, Geoffrey-A.;Farnsworth, Narman-R.;Pezzuto, John-M.;Kinghorn, A.-Douglas;Wani, Mansukh-C.;Wall, Monroe-E.
    • Archives of Pharmacal Research
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    • v.26 no.2
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    • pp.124-127
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    • 2003

  • Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassayguided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic.

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