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Bioactive Prenylated Flavonoids from the Stem Bark of Artocarpus kemando  

Seo, Eun-Kyoung (Chemistry and Life Sciences, Research Triangle Institute, College of Pharmacy, Ewha Womans University)
Lee, Dong-Ho (Chemistry and Life Sciences, Research Triangle Institute)
Shin, Young-Geun (Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois)
Chai, Hee-Byung (Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois)
Navarro, Hernan-A. (Chemistry and Life Sciences, Research Triangle Institute)
Kardono, Leonardus B.S. (Research Center for Chemistry, Indonesian Institute of Science)
Wani, Mansukh, C. (Chemistry and Life Sciences, Research Triangle Institute, College of Pharmacy, Ewha Womans University)
Rahman, Ismail (Herbarium Bogoriense, Research Center for Bilogy, Indonesian Institute of Science)
Cordell, Geoffrey-A. (Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illionois)
Farnsworth, Narman-R. (Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illionois)
Pezzuto, John-M. (Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illionois)
Kinghorn, A.-Douglas (Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illionois)
Wani, Mansukh-C. (Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illionois)
Wall, Monroe-E. (Chemistry and Life Sciences, Research Triangle Institute, College of Pharmacy, Ewha Womans University)
Publication Information
Archives of Pharmacal Research / v.26, no.2, 2003 , pp. 124-127 More about this Journal
Abstract
Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassayguided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic.
Keywords
Artocarpus kemando; Moraceae; Flavonoids; LC-MS dereplication; Cytotoxicity; DNA strand-scission activity;
Citations & Related Records

Times Cited By Web Of Science : 9  (Related Records In Web of Science)
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