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항헬리코박터 IgY 항체의 위염(위궤양) 치료효과에 관한 연구

Study on the Effect of Chicken Egg Containing IgY against Helicobacter pylori

  • 발행 : 2003.12.01

초록

면역 물질인 IgY가 함유된 다기능성 계란 섭취로 인체에서 H. priori제균 치료에 어떠한 효과를 나타내는지 알아보고자 H. pylori 양성인 위염 환자 63명을 대상으로 임의로 IgY 함유 계란 투여군(17명), 항생제 투여군(17명) 및 항생제와 IgY 함유 계란 병합투여군(16명)으로 나누고 2주간 치료하였고 IgY 정제 투여군(13명)은 1개월간 치료하였다. 치료후 H. pylori 박멸률, $^{13}$$CO_2$ 변화율($\Delta$$^{13}$$CO_2$) 및 updated sydney system에 따른 H. pylori 균체 밀도, 급만성 염증 활성도, 장상피화생을 비롯한 위축도등의 조직학적 변화에 대한 시험결과는 다음과 같다. IgY 함유 계란 투여군, 항생제 투여군, 항생제와 IgY 함유 계란 병합투여군 및 IgY 정제 투여군에서 H. pylori 박멸률은 각각 0%, 88%, 94% 및 0%로 IgY 함유 계란을 항생제와 병합투여 했을 때 항생제만 투여할 때 보다 H. pylori 박멸률이 높게 나타났지만 유의성은 없었다. IgY함유 계란 투여군 17명중 1명이 $\Delta$$^{13}$$CO_2$이 감소하는 경향을 보였지만 나머지는 변함이 없었다. 항생제와 IgY 함유 계란 병합투여군 16명중 15명에서 치료 1주째 $\Delta$$^{13}$$CO_2$이 모두 4이하로 치료전보다 유의하게 감소하였으며 (p<0.05), 나머지 1명도 치료 1주와 2주째 $\Delta$$^{13}$$CO_2$이 치료 전에 비해 감소하는 경향을 보였다. IgY 함유 계란 투여군과 IgY 정제 투여군에서 위전정부의 급성 염증 활성도가 유의하게 감소하였다 (p<0.01). IgY 함유 계란 투여군과 IgY 정제 투여군에서 위전정부의 H pylori 균체 밀도가 유의하게 감소하였다 (p<0.05). IgY정제 투여군에서 위체부의 만성 염증 활성도가 감소하는 경항을 보였다. IgY 함유 계란 투여군에서 위전정부 및 위체부의 장상피화생과 위축도는 치료전후 변화가 없었다. IgY정제 투여군의 1예에서만 치료전 위전정부에 경도의 장상피화생이 관찰되었으며 치료후 정상으로 호전되었다. 위점막 위축은 대상환자 모두에서 치료전후 변화가 없었다.

This study was conducted to investigate the effect of chicken egg containing IgY against H. pylori in patients with gastritis. Sixty three H. pylori-infected volunteers (20∼43 year, Male Female=49 : 14) were randomized into four groups which were treated with one chicken egg containing IgY b.i.d. (IgY group; n=17) or omeprazole 20 mg b.i.d., amoxicillin 1.0 g b.i.d. and clarithromycin 500 mg b.i.d. (OAC group; n=17) or omeprazole 20 mg b.i.d., amoxicillin 1.0 g b.i.d., clarithromycin 500 mg b.i.d. and one chicken egg containing IgY b.i.d. (OAC with IgY group; n=16) for 2 weeks or lyophilized IgY 1 g b.i.d (lyophilized IgY group) for 1 month. $\Delta$$^{13}$ $CO_2$ before and after treatment, the eradication rate of H. pylori and histologic change including H. pylori density, acute and chronic inflammation activity, intestinal metaplasia and glandular atrophy by updated sydney system were evaluated. Eradication rate of OAC with IgY group (94%) was higher than IgY group (0%), lyophilized IgY group (0%) and OAC group (88%). $\Delta$$^{13}$ $CO_2$at 2 weeks after treatment in one patient of IgY group was decreased. But that was not changed in the other patients. $\Delta$$^{13}$ $CO_2$ at 1 week after treatment in 15 patients of OAC with IgY group was significantly lower than pretreatment level (p<0.05), and $\Delta$$^{13}$ $CO_2$ at 1 week and 2 week after treatment was decreased in the other patient. Acute inflammation activity at antrum was significantly decreased after treatment in IgY and lyophilized IgY group (p<0.01), H. pylori density at antrum was significantly decreased after treatment in IgY and lyophilized IgY group (p<0.05). Chronic inflammation activity at body was decreased after treatment in lyophilized IgY group. Intestinal metaplasia and glandular atrophy at antrum and body were not changed after treatment in IgY group. Mild intestinal metaplasia in one patient of lyophilized IgY group changed to normal after 1 month treatment. Gandular atrophy at antrum and body were not changed after treatment in lyophilized IgY group.

키워드

참고문헌

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피인용 문헌

  1. Synergistic Inhibition of IgY, Auricularia auricula, and Lactic Acid Bacteria from Kimchi and Tarak on Helicobacter pylori vol.26, pp.1, 2013, https://doi.org/10.9799/ksfan.2013.26.1.035
  2. Effects of Dietary Supplementation of Macsumsuk and Herb Resources on Egg Performance and Quality in Korean Native Crssbred Chicken vol.54, pp.2, 2012, https://doi.org/10.5187/JAST.2012.54.2.125
  3. Comparison of principle components and quality of eggs by laying hen breeds vol.27, pp.5, 2016, https://doi.org/10.7465/jkdi.2016.27.5.1307