Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Improve Effects of Saengshik on Patient with Fatty Liver and Hyperlipidemia in Murine

생식 섭취가 지방간 개선 및 지질 대사에 미치는 영향

  • 송미경 ((주)이롬라이프 생명과학연구원) ;
  • 홍성길 ((주)이롬라이프 생명과학연구원) ;
  • 황성주 ((주)이롬라이프 생명과학연구원) ;
  • 박옥진 (한남대학교 식품영양학과) ;
  • 박미현 ((주)이롬라이프 생명과학연구원)
  • Published : 2003.10.01
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Abstract

To examine the effect of Saengshik on parameters related to hepatoprotective, anthropometric, blood pressure, serum lipid and blood related indices, nonalcoholic fatty liver subjects were treated with two meal portion of Saengshik in the replacement of meals for a period of three months. Weight, Body Mass Index (BMI) and systolic blood pressure were significantly decreased after the treatment. Chronically elevated serum aspartate aminotransferase (AST), gamma-Glutamyl transferase (r-GTP) and Alkaline Phosphatase (ALP) levels showed reduction to the near normal range. Serum total triglyceride level were reduced following the treatment. Whereas, there were no changes of serum total cholesterol with Saengshik consumption. Also, additional study was conducted to investigate the effect of Saengshik supplementation to high cholesterol and fat diet on lipid metabolism in rats. Male Spraque-Dawley rats were administrated hyperlipidemiainducing diet containing 1% cholesterol and 10% lard to induce hyperlipidemia for 4 weeks and were fed on diet containing Saengshik (30%, w/w) for 7 weeks. The feeding of diet containing 30% Shaengshik significantly decreased total cholesterol (TC) contents and total triglyceride. These results demonstrate Saengshik may be beneficial for fatty liver patients in improving their lipid metabolism.

지방간 소견을 나타낸 12인의 피검자를 대상으로 하여 3개월간 1일 2회, 아침과 저녁 식사를 생식으로 대용시킨 후 3개월후 혈액 및 신체계측 조사를 통하여 생식의 지방간 개선 효과를 관찰하였다. 그 결과 생식 섭취 3개월후 체지방 양 및 체중의 감소가 나타났으며, 간손상의 지표로 사용되는 AST, ALT, r-GTP 및 ALP의 활성이 모두 유의적으로 저하되는 모습이 관찰되어 생식의 섭취가 지방간을 개선시키는데 유용한 도구가 될 수 있는 것으로 판명되었다. 생식의 지방간 개선 기작을 탐구하기 위하여 고지방 사료를 통하여 흰 쥐에게 고지혈증을 유도한 이후 생식을 6주간 섭취시킨 결과에서도 실험 동물의 혈중 콜레스테롤, 중성지방의 농도가 모두 낮아지는 것으로 나타나 생식 섭취가 체내지질 대사의 정상화에 기여하는 능력이 있는 것으로 판단되었다. 지방간은 다양한 원인에 의해서 발생되나 그 중 가장 중요한 인자는 체내 높은 지방 함량이라 할 수 있으며, 생식의 섭취는 체내 지질 대사를 정상화함으로서 지방간의 개선에 높은 효과를 발휘 할 수 있을 것으로 추측된다.

Keywords

References

  1. Nutritional liver disease: Pathology of the liver Nayak,N.C.;Roderick,N.;Macsween,M.;Peter,D.;Anthony P. Curchill livingstone
  2. Human Biochem Fatty acid metabolism in liver James,M.O.;Otto,W.N.
  3. Am J Gastro v.84 The useful BCAA in patients with acute or chronic hepatic encephalopahty William,F.A.;enrique,S.
  4. Am J Gastro v.83 Nutrition, alcohol and liver Archord,J.
  5. Gastroenterology v.97 Parenteral nutrition with branched chain amino acids in hepatic encephalopathy Naylor,C.D.;O'Rouke,K.;Detsky,A.S.;Baker,J.P.
  6. Dig Dis v.20 no.12 Biochemical and clinical consideration Hoyumpa,A.M.;Greene,H.L.;Dunn,G.D.;Shenker S. Fatty Liver https://doi.org/10.1007/BF01070758
  7. J Lipid Res v.14 Effects of ethanol on the metabolism of fre fatty acids in isolated liver cells Ontko,J.A.
  8. Gastroenterology v.50 Study of agents for the prevention of the fatty liver prolonged alcohol intake Lieber,C.S.;Decarli,L.M.
  9. Disease of the liver and bilisry system (8th ed.) Disease of the liver and bilisry system Moon,H.N.;Hong,S.J.;Suh,S.J.
  10. Kor J Nutr v.25 no.5 The Prevalence of Obesity in Children and Adolescents Moon,H.N.;Hong,S.J.;Suh.S.J.
  11. Kor Pediatrics v.32 The Obesity in Children and Adolescents Jo,K.B.;Park,S.B.;Park,S.C.;Lee,D.H.Suh,S.J.
  12. Kor J Nutr v.28 no.7 Improvement of liver function by weight control in children with fatty liver Park,H.S.;Shin,E.S.;Kim,M.W.;Kim,K.M.
  13. Autumn symposium of Korean society of food science and nutrition The present states and prospect of Shaengshik
  14. New Eng J Med v.295 no.1 Childhood antecedents of adult obesity Charney,E.;Goodman,H.C.;Mebnride,M.;Lyon,B.;Pratt,R. https://doi.org/10.1056/NEJM197607012950102
  15. Dig Dis Sic v.26 Hepatic morphology in obesity Nasrallah,S.M.;Willis,C.E.;Galambos,J.T. https://doi.org/10.1007/BF01308373
  16. Biochem Pharm v.34 Folate metabolism, the enterohepatic circulation and alcohol Weir,D.G.;Ging,P.G.;Scott,J.M. https://doi.org/10.1016/0006-2952(85)90092-9
  17. Radiology v.162 Obesity-related nonalcohoic fatty liver: CT features and follow-up studies after low calorie diet Nomura,F.;Ohnishi,K.;Ochiai,T.;Okuida,K.
  18. 7th International Congress on obesity sup(2) Effect of weight control on hepatic abnormalities in obese patients with fatty liver Park,H.S.;Shin,E.S.;Kim,M.W.
  19. Clin Chem v.23 no.4 Diagnostic effectiveness of biochemical liver-function tests as evaluated by discriminant function analysis Sher,P.
  20. Teschke R, Neuefeind M, Nishimura M, Strohmeyer G. Hepatic gamma-glutamyltransferase activity in alcoholic fatty liver: comparison with other liver enzymes in man and rats. Gut 24(7): 625-630. 1983 https://doi.org/10.1136/gut.24.7.625
  21. Gut v.24 no.7 Hepatic gamma-glutamyltransferase activity in alcoholic fatty liver:comparison with other liver enzymes in man and rats Teschke,R.;Neuefeind,M.;Nishimura,M.;Strohmeyer,G. https://doi.org/10.1136/gut.24.7.625
  22. Hypertens Res v.24 no.4 Correlation between fatty liver and coronary risk factors: a population study of elderly men and women in Nagasaki Akahoshi,M.;Amasaki,Y.;Soda,M.;Tominaga,T.;Ichimaru,S.;Nakashima,E.;Seto,S.;Yano,K. https://doi.org/10.1291/hypres.24.337
  23. Semin Liver Dis v.21 no.1 Treatment of nonalalcoholic fatty liver: present and emerging therapies Angulo,P.;Lindor,K.D. https://doi.org/10.1055/s-2001-12931
  24. J Korean Soc Food Nutr v.25 no.3 Effects of dietary fibers on cholesterol metabolism in cholesterol-fed rats Jeong,L.Y.;Suh,M.J.;Song,Y.S.
  25. J Korean Soc Food Sci Nutr v.27 no.6 Effect of fiber on serum lipid metabolism in rats with dirt-induced cholesterolemia Jang,J.Y.;Lee,M.K.;Kim,M.J.;Cho,S.Y.
  26. J Human Nutr v.35 Plasma cholesterol and pressure in egetarians Burr,M.L.;Bates,A.M.;Leger,A.S.
  27. Proc Natl Soc v.36 Serum cholesterol and triglyceride concentration in vegans Sanders,T.A.B.;Ellis,F.R.;Dickerson,J.W.T.
  28. Am J Clin Nutr v.33 Interaction with bile acid, phospholipid, cholesterol and triglyceride with dietary fibers in the small intestine in the rat Ebihara,K.;Schneeman,B.O.
  29. J Nutr v.106 Comparison of the binding of various bile acid and bile salts in vivo by several types of fiber Story,J.A.;Kritchevsky,D.
  30. Lipid v.25 Contrasting effects of water-soluble and water-insoluble dietary fiber on bile acid conjugation and taurine metabolism in the rat Ide,T.;Horii,M.;Yamamoto,T.;Kawashima,K. https://doi.org/10.1007/BF02544343
  31. Am J Clin Nutr v.32 Plant fiber, Carbohydrate and lipid metabolism Anderson,J.W.;Chen,W.L.
  32. J Nutr v.120 Comparison between physiological effects of konjac-glucomannan and propionate in baboons fed "Western" diets Venter,C.S.;Vorster,H.H.;Van der Nest D.G.