Transactions of the Korean Society of Mechanical Engineers A (대한기계학회논문집A)

The Korean Society of Mechanical Engineers (대한기계학회)
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A Study of Adaptive Bone Remodeling by Cellular Automata Method

복잡계의 세포자동화법을 이용한 뼈의 적응적 재구축에 관한 연구

  • 문병영 (부산대학교 항공우주공학과) ;
  • 박정홍 (부산대학교 대학원 기계설계공학과) ;
  • 손권 (부산대학교 기계공학부)
  • Published : 2003.07.01
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Abstract

An adaptive bone remodeling is simulated by using the cellular automata (CA) method. It is assumed that bone tissue consist of bone marrow, osteoclast, osteoblast cell or osteoprogenitor cell. Two types of local rule are adopted; those are the metabolism rule and adaptive bone formation rule. The metabolism rule is based on the interactions of cells and the bone formation rule is based on the adaptation against the mechanical stimulus. The history of load and memory of mechanical stimulus are also considered in the local rules. As a result, the pattern of distribution of the bone tissue is dynamically adequate and it is similar to intact cancellous bone.

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References

  1. Wolff J., 1869, 'Ueber die Bedeutung der Architectur der Spongiosen fur die Frage vom Knochenwachsthum,' Zentralblatt fur die Medizinischen Wissenschaften, pp. 223-234
  2. Carter, D. R., Fyhrie, D. P. and Whalen, R. T., 1987, 'Trabecular Bone Density and Loading History: Regulation of Connective Tissue Biology by Mechanical Energy,' Journal of Biomechanics, Vol. 20 No. 8, pp. 785-794 https://doi.org/10.1016/0021-9290(87)90058-3
  3. Carter, D. R., 1987, 'Mechanical Loading History and Skeletal Biology,' Journal of Biomechanics, Vol. 20 No. 11/12 ,pp.1095-1109 https://doi.org/10.1016/0021-9290(87)90027-3
  4. Fyhrie, D. P. and Carter, D. R., 1990, 'Femoral Head Apparent Density Distribution Predicted from Bone Stresses,' Journal of Biomechanics, Vol. 23, No. 1, pp. 1-10 https://doi.org/10.1016/0021-9290(90)90363-8
  5. Carter, D. R., Orr, T. E. and Fyhrie, D. P., 1989, 'Relationships between Loading History and Femoral Cancellous Bone Architecture,' Journal of Biomechanics, Vol. 22, No. 3, pp. 231-244 https://doi.org/10.1016/0021-9290(89)90091-2
  6. Beaupre, G. S., Orr, T. E. and Carter, D. R., 1990, 'An Approach for Time-Dependent Bone Modeling and Remodeling: Theoretical Development,' Journal of Orthopaedic Research, Vol. 8, pp. 651-661 https://doi.org/10.1002/jor.1100080506
  7. Beaupre, G. S., Orr, T. E. and Carter, D. R., 1990, 'An Approach for Time-Dependent Bone Modeling and Remodeling: A Preliminary Remodeling Simulation,' Journal of Orthopaedic Research, Vol. 8, pp. 662-670 https://doi.org/10.1002/jor.1100080507
  8. Orr, T. E., Beaupre, G. S., Carter, D. R. and Schurman, D. J., 1990, 'Computer Predictions of Bone Remodeling around Porus-Coated Implants,' Journal of Arthroplasty, Vol. 5, No. 3, pp. 191-200 https://doi.org/10.1016/S0883-5403(08)80074-5
  9. Huiskes, R., Weinans, H., Grootenboer, H. J., Dalstra, M., Fudala, B. and Slooff, T. F., 1987, 'Adaptive Bone-Remodeling Theory Applied to Prosthetic-Design Analysis,' Journal of Biomechenics., Vol. 20, No. 11/12, pp. 1135-1150 https://doi.org/10.1016/0021-9290(87)90030-3
  10. Huiskes, R., Weibans, H. and Van Rietbergen, B., 1992, 'The Relationship between Stress Shielding and Bone Resorption around Total Hip Stems and the Effects of Flexible Materials,' Clinical Orthopaedics and related Research, Vol. 274, pp. 124-134
  11. Weinans, H., Huiskes, R. and Grootenboer, H. J., 1992, 'The Behavior of Adaptive Bone-Remodeling Simulation Models,' Journal of Biomechanics, Vol. 25, No. 12, pp. 1425-1441 https://doi.org/10.1016/0021-9290(92)90056-7
  12. Weinans, H., Huiskes, R. and Grootenboer, H. J., 1992, 'Effects of Material Properties of Femoral Hip Components on Bone Remodeling,' Journal of Orthopaedic Research, Vol. 10, pp. 845-853 https://doi.org/10.1002/jor.1100100614
  13. Weinans,H., Huiskes,R. and Grootenboer,H.J., 1994, 'Effects of Fit and Bonding Characteristics of Femoral Stems on Adaptive Bone Remodeling,' Trans.ASME, Journal of Biomechanical Engineering., Vol. 116, pp. 393-400 https://doi.org/10.1115/1.2895789