Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지

A case of Discoid Lupus Erythematosus (DLE) in a Golden Retriever dog

골든 리트리버종에서 발생한 Discoid Lupus Erythematosus(DLE)의 발생 증례

  • Won, Dong-Sun (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Hong, Eun-Sil (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Jung, Man-Bok (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kim, Hyun-Jin (Department of Veterinary Pathology, College of Veterinary Medicine, Chonnam University) ;
  • Park, Nam-Yong (Department of Veterinary Pathology, College of Veterinary Medicine, Chonnam University) ;
  • Park, Chul (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Jung, Byung-Hyun (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Park, Hee-Myung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
  • 원동선 (건국대학교 수의과대학 내과학교실) ;
  • 홍은실 (건국대학교 수의과대학 내과학교실) ;
  • 정만복 (건국대학교 수의과대학 내과학교실) ;
  • 김현진 (전남대학교 수의과대학 병리학교실) ;
  • 박남용 (전남대학교 수의과대학 병리학교실) ;
  • 박철 (건국대학교 수의과대학 내과학교실) ;
  • 정병현 (건국대학교 수의과대학 내과학교실) ;
  • 박희명 (건국대학교 수의과대학 내과학교실)
  • Published : 2003.03.01
Download PDF
⟨ Previous Next ⟩

Abstract

A 3-year-old, 38 kg, male Golden Retriever dog was referred to Veterinary Teaching Hospital of Konkuk University because of chronic formation of crust on nasal bridge and planum nasale. Abnormalities of physical examination included hyperkeratosis on the footpad, symmetrical alopecia and erythma around olecranon, and crust on nasal bridge and planum nasale. Results of the hematological examination showed a mild leukopenia with neutropenia, monocytosis, and mild lymphocytosis. In addition, the result of serum chemistry and thyroid gland profile were normal. Results of fungal and bacterial culture was negative. Acanthocytes in cytological evaluation of nasal crust were observed in direct microscopic examination. Examination of skin biopsy exhibited vacuolation of basal cell layer, degeneration and necrosis of basal cell with defluxion, mild monocytes filtrations between epidermis and dermis, and mild acanthosis with hyperkeratinization. Based on results of examination described above, Discoid Lupus Erythematosus (DLE) was diagnosed.

Keywords

References

  1. Res Vet Sci v.53 Immune-mediated in the old English sheepdog Day MJ;Penhale WJ https://doi.org/10.1016/0034-5288(92)90090-O
  2. J Vet Med Sci v.57 A canine case of discoid lupus erythematosus with circulating autoantibody Iasaki T;Shimizu M;Obata H;Yanai T;Kitagawa H;Sasaki Y https://doi.org/10.1292/jvms.57.1097
  3. The 5-minute veterinary consult clinical companion small Animal Dermatology Lippincott Williams & Wilkins(1st ed.) Karen Helton Rhodes
  4. Small animal dermatology color atlas and therapeutic guide(1st ed.) Linda Medleau;Keith A. Hnilica
  5. Am J Vet v.63 Influence of long-term treatment with tetracycline and niacinamide on antibody production in dogs with discoid lupus erythematosus Mueller RS;Fieseler KV;Bettenay SV;Rosychuk RA https://doi.org/10.2460/ajvr.2002.63.491
  6. Vet Immunol Immunopathol v.5 Diagnosis of autoimmune skin disease in the dog: correlation between histopathologic, direct immunofluorescent and clinical findings Werner LL;Brown KA;Halliwell RE https://doi.org/10.1016/0165-2427(83)90031-4
  7. Vet Clin North Am Small Anim Pract v.24 Diseases of the nasal planum White SD https://doi.org/10.1016/S0195-5616(94)50106-2
  8. J Am Vet Med Assoc v.200 Use of tetracycline and niacinamide for treatment of autoimmune skin disease in 31 dogs White SD;Rosychuk RA;Reinke SI;Paradis M