Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effects of Psyllium Husk and Glucomannan on Serum Lipids, Fecal Fat Excretion and Body Fat in Rats Fed High-Fat Diet

차전자피와 글루코만난의 혼합 첨가가 고지방 식이를 한 흰쥐의 혈청지질과 변지방배설 및 체지방에 미치는 영향

  • Published : 2003.04.01
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Abstract

This study was conducted to determine the effect of a mixture of two water-soluble dietary fibers, psyllium husk and glucomannan, on serum lipids, fecal fat excretion and body fat. Twenty one female Sprague-Dawley rats were randomly assigned into three groups (control, pair-fed control and test group) and fed a high saturated fat (20% lard) diet (control diet) or a test diet (psyllium husk and glucomannan added to the control diet at the level of 0.9% and 0.68%, respectively) for 8 weeks. Pair-fed control rats were allowed to eat the amount of diet consumed by test group the preceding day. The body weight gain and food efficiency ratio of test group were significantly lower compared with these of control group. The mean values of body weight gain and food efficiency ratio were lower in test group than in pair-fed control group, but the difference was not significant. There were no differences in food intake. The dry weight and water content of feces and fecal fat excretion were markedly greater in test group than in control groups. Serum total cholesterol and triacylglycerol levels were significantly lower in test group than in two control groups.1'he rats of two control groups had higher body fat contents than that of test group. These results indicate that the combination of the two water-soluble dietary fibers, psyllium husk and glucomannan, can be used as a potent lipid-lowering agent in individuals consuming high saturated fat diet.

비슷한 특성을 보이는 두 가지의 수용성 식이섬유, 차전자피와 glucomannan는 모두 혈청 지질과 변 배설, 체지방 감소에 효과가 있을 것으로 기대되고 있다. 본 연구는 흰쥐를 대상으로 20% 고포화지방 식이와 동시에 식이 무게의 1.58%에 해당하는 차전자피와 glucomannan의 혼합분말을 8주간 섭취하게 하고 체중과 혈청지방 및 변배설, 그리고 체지방의 변화를 조사하였다. 실험군은 대조군과 pair-fed control군, 식이섬유 섭취군으로 구성하였다. 본 연구 결과 차전자피와 glucomannan은 수용성 식이섬유 중 비교적 적은 복용량으로 체중을 감소시키고, 변의 건조 중량, 수분 함량, 지방함량 등을 유의적으로 증가시켜 부작용 없이 변 배설을 도와주었으며 장에서 지방의 흡수를 억제하고 혈청 콜레스테롤과 중성지방의 농도를 유의적으로 낮추어줌으로서 바람직한 체지방 저하 효과를 보였다. 위와 같은 결과들은 차전자피와 glucomannan의 혼합투여가 체지방 감소와 혈청지질 개선, 변비 해소 등에 효과적인 방법이며 특히 지방 섭취가 많은 현대인에게 지방 배설을 유도할 수 있는 방법임을 시사한다.

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References

  1. Grundy SM. 1998. Multifactorial causation of obesity: implications for prevention. Am J Clin Nutr 67 (suppl): 563s-572s. https://doi.org/10.1093/ajcn/67.3.563S
  2. Oku T, Tokunaga T, Hosoya N. 1985. Neosugar-A fructooligosaccharide nonnutritive sweetener. Nutr Rev 43: 155-156. https://doi.org/10.1111/j.1753-4887.1985.tb06898.x
  3. Ide T, Okamatsu H, Sugano M. 1985. Regulation by dietary fats of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in rat liver. J Nutr 108: 409-424.
  4. Chai YM, Rhee SJ. 2001. Effects of dietary oligosaccharide on the blood glucose and serum lipid composition in streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr 30: 710-716.
  5. Lee KH, Park MA, Kim ES, Moon HK. 1994. A study on dietary fiber intakes of Korean. J Korean Soc Food Nutr 23: 767-773.
  6. Lee HS, Lee YK, Seo YJ. 1994. Annual changes in the estimated dietary fiber intake of Korean during 1969-1990. Korean J Nutrition 27: 59-71.
  7. The Korean Nutrition Society. 2000. Recommended dietary allowances for Koreans. 7th Revision. Joongangmoonhwasa, Seoul.
  8. Lee MR. 1999. Physiological effects of sponge cakes containing oligosaccharides. MS Thesis. Chungnam National University, Korea. p 40-41.
  9. Cho JH. 2000. Effects of fructooligosaccharides and sponge cakes containing fructooligosaccharides on the rat's intestine and serum lipids. MS Thesis. Chungnam National University, Korea. p 25-26.
  10. Gallaher CM, Munion J, Hesslink R Jr, Wise J, Gallaher DD. 2000. Cholesterol reduction by glucomannan and chitosan is mediated by changes in cholesterol absorption and bile acid and fat excretion in rats. J Nutr 130: 2753-2759. https://doi.org/10.1093/jn/130.11.2753
  11. Gelissen IC, Brodie B, Eastwood MA. 1994. Effect of plantago ovata (psyllium) husk and seeds on sterol metabolism: studies in normal and ileostomy subjects. Am J Clin Nutr 59: 395-400. https://doi.org/10.1093/ajcn/59.2.395
  12. Anderson JW, Floore TL, Geil PB, O'Neal DS, Balm TK. 1991. Hypocholesterolemic effects of different bulk-forming hydrophilic fibers as adjuncts to dietary therapy in mild to moderate hypercholesterolemia. Arch Intern Med 151: 1597-1602. https://doi.org/10.1001/archinte.151.8.1597
  13. Walsh DE, Yaghoubian V, Behforooz A. 1984. Effect of glucomannan on obese patients: a clinical study. Int J Obes 8: 289-293.
  14. Arvill A, Bodin L. 1995. Effect of short-term ingestion of konjac glucomannan on serum cholesterol in healthy men. Am J Clin Nutr 61: 585-589. https://doi.org/10.1093/ajcn/61.3.585
  15. Vido L, Facchin P, Antonello I, Gobber D, Rigon F. 1993. Childhood obesity treatment: double blinded trial on dietary fibers (glucomannan) versus placebo. Padiatr Padol 28: 133-136.
  16. Bligh EG, Dyer WJ. 1959. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37: 911-917. https://doi.org/10.1139/o59-099
  17. Fiordaliso M, Kok N, Desager KP, Goethals F, Deboyser D, Roberfroid M, Delzenne N. 1995. Dietary oligofructose lowers triglycerides, phospholipids and cholesterol in serum and very low density lipoproteins of rats. Lipids 30: 163-167. https://doi.org/10.1007/BF02538270
  18. Hou YH, Zhang LS, Zhou HM, Wang RS, Zhang YZ. 1990. Influence of refined konjac meal on the levels of tissue lipids and the absorption of four minerals in rats. Biomed Environ Sci 3: 306-314.
  19. Vahouny GV, Khalafi R, Satchithanandam S, Watkins DW, Story JA, Cassidy MM, Kritchevsky D. 1987. Dietary fiber supplementation and fecal bile acid, neutral steroids and divalent cations in rats. J Nutr 117: 2009-2015. https://doi.org/10.1093/jn/117.12.2009
  20. Kritchevsky D, Tepper SA, Klurfeld DM. 1995. Influence of psyllium presentations on plasma and liver lipids of cholesterol-fed rats. Artery 21: 303-311.
  21. Arlian LG, Vyszenski-Moher DL, Lawrence AT, Schrotel KR, Ritz HL. 1992. Antigenic and allergenic analysis of psyllium seed components. J Allergy Clin Immunol 89: 866-876. https://doi.org/10.1016/0091-6749(92)90443-6
  22. Slavin JL. 1994. Epidemiologic evidence for the impact of whole grains on health. Crit Rev Food Sci Nutr 34: 427-434. https://doi.org/10.1080/10408399409527672
  23. Yamada K, Tokunaga Y, Ikeda A, Ohkura K, Mamiya S, Kaku S, Sugano M, Tachibana H. 1999. Dietatry effect of guar gum and its partially hydrolyzed product on the lipid metabolism and immune function of Sprague-Dawley rats. Biosci Biotechnol Biochem 63: 2163-2167. https://doi.org/10.1271/bbb.63.2163
  24. Hozumi T, Yoshida M, Ishida Y, Mimoto H, Sawa J, Doi K, Kazumi T. 1995. Long-term effcts of dietary fibersupplementation on serum glucose and lipoprotein levels in diabetic rats fed a high cholesterol diet. Endocr J 42: 187-192. https://doi.org/10.1507/endocrj.42.187

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