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Effect of Monascus koji on Blood Pressure and Serum Cholesterol Composition of SHR by Chronic Dietary Administration

홍국 장기투여가 SHR의 혈압 및 혈중 콜레스테롤 조성에 미치는 영향

  • 류미라 (한국식품개발연구원) ;
  • 김은영 (한국식품개발연구원) ;
  • 한진수 (㈜바이오제노믹스 해은생명과학연구소)
  • Published : 2003.04.01

Abstract

The antihypertensive and cholesterol- lowering effects of Monascus koji (M. koji) prepared with Monascus ruber IFO32318 were examined in spontaneously hypertensive rats (SHR). Control was fed a normal diet and groups I, II or III were fed diets containing 0.03%, 0.1% or 0.3% M. koji for 8 weeks, respectively. After 8 weeks, all animals were fed normal diets in the following 2 weeks. The blood pressure of rats fed M. koji added diets were significantly attenuated as compared with control and the diet containing high concentration of M. koji had a tendency of stronger antihypertensive effect. These differences lasted throughout the experimental period when they were fed experimental diet. For 2 weeks after the 8 weeks of experimental diet all groups were fed the same normal diet and the differences of blood pressure caused by M. koji disappeared. In rats fed the M. koji added diet, the serum total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C) were not differed compared with control, but VLDL cholesterol (VLDL-C) was significantly lowered. M koji also significantly decreased serum risk factors, both TC/HDL-C ratio and non HDL-C/HDL-C ratio. Consequently, it is suggested that M. koji may play an important role to attenuate hypertension and to improve serum lipid Profiles.

홍국의 장기섭취가 자연발증 고혈압 쥐(SHR)의 혈압상승 및 혈중 콜레스테롤 조성에 미치는 영향을 조사하였다. Monascus ruber IFO 32318 균주로 제조한 홍국을 각각 0.03%, 0.1%, 0.3% 첨가한 식이를 8주간 섭취시킨 후 모든 실험군을 일반식이로 전환시켜 다시 2주간 사육하였다. 식이섭취 2주 째부터 대조군에 비해 홍국 섭취군에서 수축기혈압, 이완기 혈압 및 평균혈압의 유의적인 상승 억제효과가 나타났으며 그 효과는 식이에 첨가된 홍국의 양에 비례하였고 홍국첨가 식이를 중단하면 실험군 간의 각 혈압의 유의적인 차이는 사라졌다. 또한 홍국은 SHR의 혈중 VLDL-C의 함량을 유의적으로 저하시켰으며 TC 및 LDL-C은 홍국 첨가량이 많을수록 낮은 경향을 나타내었고 HDL-C은 대조군, group I 및 group II가 거의 동일하였으며 홍국 첨가량이 가장 많은 group III에서만 약간 높은 경향을 나타내었다. 또한 동맥경화의 지표가 되는 TC과 HDL-C의 비율 및 non-HDL-C과 HDL-E의 비율은 홍국 섭취량이 증가할수록 감소하는 경향을 보였고 LDL-C과 HDL-C의 비율 또한 홍국 섭취군이 대조군보다 유의적으로 낮은 값을 나타내었다. 이러한 모든 효과는 홍국을 식이 섭취량의 0.1% 이상 첨가한 실험군에서 뚜렷이 나타났다.

Keywords

References

  1. Endo A. 1985. Trends in Monascus koji and Monascus strains. Hako To Kogyo 43: 544-552.
  2. Endo A. 1979. Monacolin, a new hypocholesterolemic agent produced by a Monascus species. J Antibiotics 3: 852-854.
  3. Endo A. 1980. Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase. J Antibiotics 3: 334-336.
  4. Tsuji K, Ichikawa T, Tanabe N, Abe S, Tarui S, Nakagawa Y. 1992. Effects of two kinds of koji on blood pressure in spontaneously hypertensive rats. Nippon Nogeikagaku Kaishi 66: 1241-1246. https://doi.org/10.1271/nogeikagaku1924.66.1241
  5. Tsuji K, Ichikawa T, Tanabe N, Abe S, Tarui S, Nakagawa Y. 1992. Antihypertensive activities of beni-koji extracts and $\gamma$-aminobutyric acid in spontaneously hyeprtensive rats. Jpn J Nutr 50: 285-291. https://doi.org/10.5264/eiyogakuzashi.50.285
  6. Tsuji K, Ichikawa T, Tanabe N, Obata H, Abe S, Tarui S, Nakagawa Y. 1992. Effect of mycelial weight on hypotensive activity of beni-koji in spontaneously hypertensive rats. Nippon Shokuhin Kogyo Gakkaishi 39: 790-795. https://doi.org/10.3136/nskkk1962.39.790
  7. Rhyu MR, Kim DK, Kim HY, Kim BK. 2000. Nitric oxidemediated endothelium-dependent relaxation of rat thoracic aorta induced by aqueous extract of red rice fermented with Monascus ruber. J Ethnopharm 70: 29-34. https://doi.org/10.1016/S0378-8741(99)00132-4
  8. Rhyu MR, Kim EY, Kim HY, Ahn BH, Yang CB. 2000. Characteristics of the red rice fermented with fungus Monascus. Food Sci Biotechnol 9: 21-26.
  9. American Institute of Nutrition. 1977. Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies J Nutr 107: 1340-1348. https://doi.org/10.1093/jn/107.7.1340
  10. SAS Institute Inc. 1985. SAS User's Guide. Cary, NC, USA.
  11. Rhyu MR, Kim EY. 2002. The relation between antihypertensive effect and $\gamma$-aminobutyric acid, mycelial weight and pigment of Monascus. Kor J Food Sci Technol 34: 737-740.
  12. Rhyu MR, Kim EY, Han JS. 2002. Antihypertensive effect of the soybean paste fermented with the fungus Monascus. Int J Food Sci Technol 37: 585-588. https://doi.org/10.1046/j.1365-2621.2002.00599.x
  13. Rader DJ, Davidson MH, Caplan RJ, Pears JS. 2003. Lipid and apolipoprotein ratios: association with coronary artery disease and effects of rosuvastatin compared with atorvastatin, pravastatin, and simvastatin. Am J Cardiol 91(suppl): 20C-24C https://doi.org/10.1016/S0002-9149(03)00005-5
  14. Endo A. 1979. Monacolin K, a new hypocholesterolemic agent produced by a Monascus species. J Antibiotics 32: 852-854. https://doi.org/10.7164/antibiotics.32.852
  15. Endo A. 1985. Compactin (ML-236B) and related compounds as potential cholesterol-lowering agents that inhibit HMGCoA reductase. J Medicinal Chem 28: 401-405. https://doi.org/10.1021/jm00382a001
  16. Kroon PA, Hand KM, Huff JW, Alberts AW. 1982. The effect of mevinolin on serum cholesterol levels of rabbits with endogenous hypercholesterolemia. Atherosclerosis 44: 41-48. https://doi.org/10.1016/0021-9150(82)90051-X
  17. Arad Y, Ramakrishnan R, Ginsberg HN. 1990. Lovastatin therapy reduces low density lipoprotein apoB levels in subjects with combined hyperlipidemia by reducing the production of apoB-containing lipoproteins: implications for the pathophysiology of apoB production. J Lipid Res 31: 567-582.

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