Journal of Nutrition and Health

  • 제36권2호
  • /
  • Pages.101-108
  • /
  • 2003
  • /
  • 2288-3886(pISSN)
  • /
  • 2288-3959(eISSN)
한국영양학회 (The Korean Nutrition Society)
권호 표지

흰쥐에서 Curcuminoid 및 이를 함유한 천연식물 혼합물이 심혈관계에 미치는 영향

Effect of Curcuminoids and Natural Plants Extract Mixture on the Cardiovascular System in Rats

  • 안수현 (연세대학교 생활과학대학 식품영양학과, (주)바이오버드 심혈관치료연구실) ;
  • 이종호 (연세대학교 생활과학대학 식품영양학과) ;
  • 박하림 ((주)바이오버드 심혈관치료연구실) ;
  • 권승택 ((주)바이오버드 심혈관치료연구실) ;
  • 고유석 ((주)바이오버드 심혈관치료연구실) ;
  • 손영덕 (연세대학교 의과대학 심혈관연구소) ;
  • 장양수 (연세대학교 의과대학 심혈관연구소) ;
  • 정광회 ((주)바이오버드 심혈관치료연구실, 연세대학교 의과대학 심혈관연구소)
  • 발행 : 2003.03.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Antiplatelet aggregation, anticoagulant and lipid-lowering drugs are clinically widely used for secondary preventive purpose in the cardiovascular patients, but there is no primary preventive agents to prevent these diseases. With the aim of developing effective primary agents for cardiovascular diseases, we tried to formulate an optimized mixture of natural plants extract containing Theae sinensis, Camelliae sinensis, Vitis vinifera, Gingko folium and curcuminoids from Curcuma longa and to evaluate its anti-thrombotic and anti-hypercholesterolemic effects in vivo. The inhibitory effect of curcuminoids on vascular smooth muscle cell proliferation and migration were also investigated in vitro. in the animal experiments treated with hyperlipidemic diet, oral treatment of curcuminoids and natural plants extracts mixture (100 mg/kg) into male Sprague Dawley rats for 7 week simultaneously inhibited platelet aggregation as well as improved lipid profile in the blood. Compared to control group, both of curcuminoids-treated and mixture-treated groups revealed significantly decrease of total cholesterol (24.4%, 28.6%), free cholesterol (25.1%, 24.0%), cholesterol ester (14.6%, 29.0%), LDL-cholesterol (27.0%, 32.0%) and triglyceride (15.0%, 31.0%), respectively. However, both groups showed increase of HDL-cholesterol (46.6% and 51.5%) . In particular, atherogenic index of curcuminoids and mixture treatment group was significantly decreased to 47.0% and 56.0%, respectively. Furthermore, oral treatment of curcuminoids and mixture significantly inhibited collagen-induced platelet aggregation (21.1% and 29.1%, respectively), compared to control group. The anti-thrombotic values of mixture was almost similar to that of aspirin treatment (100 mg/kg) group. These results suggest that the oral treatment of curcuminoids-based natural plant extract mixture improved cardiovascular conditions in hyperlipidemic rats.

키워드

참고문헌

  1. J Med Pharm Soc WAKAN-YAKU v.5 Hematological studies on naturally occurring substances Okuyama T;Naru T;Kurata H;Wang JD;Hashimoto T;Takeuchi K
  2. Clin Chem v.21 Does wine work? Goldberg DM
  3. Metabolism v.32 The compatrtive reductions of the plasma lipids and lipoproteins by dietary polyunsaturated fats: Salmon oil versus vegetable oils Harris WS;Connor WE;McMurry MP https://doi.org/10.1016/0026-0495(83)90226-3
  4. Experientia v.43 A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto: a typical and popular soybean food in the Japanese diet Sumi H;Hamada H;Tsushima H;Mihara H;Muraki H https://doi.org/10.1007/BF01956052
  5. Nippon Yakurigaku Zasshi v.97 Preventive effects of green tea extract on lipid abnormalities in serum, liver and aorta of mice fed an atherogenic diet Yamaguchi Y;Hayashi M;Yamazoe H;Kunitomo M https://doi.org/10.1254/fpj.97.6_329
  6. J Nutr Sci Vitaminol v.32 Effect of green tea catechins on plasma cholesterol level in cholesterol-fed rats Murnmatsu K;Fukuyo M;Hara Y https://doi.org/10.3177/jnsv.32.613
  7. J Cell Biochem v.22 no.SUP. Polyphenols as cancer chemopreventive agents Stoner GD;Mukhtar H.
  8. J Cardiovasc Pharmacol v.38 Antiplatelet activity of green tea catechins is mediated by inhibition of cytoplasmic calcium increase Kang WS;Chung KH;Chung JH;Lee JY;Park JB;Zhang YH;Yoo HS;Yun YP https://doi.org/10.1097/00005344-200112000-00009
  9. J Cardiovasc Pharmacol v.39 Epigallocathechin-3-gallate inhibits bFGF-induced intracellular signaling transduction pathway in rat aortic smooth muscle cell Hwang KC;Lee KH;Jang YS;Yun YP;Chung KH https://doi.org/10.1097/00005344-200202000-00014
  10. Thromb Res v.96 Antithrombotic activities of green tea catechins and (-)-epigallocatechin gallate Kang WS;Lim IH;Yuk DY;Chung KH;Park JB;Yoo HS;Yun YP https://doi.org/10.1016/S0049-3848(99)00104-8
  11. Kor J Appl Microbiol Biotechnol v.23 no.1 Screening and identification of the fibrinolytic bactierial strain from Chungkook-jang Kim YT;Kim WK;Oh HI
  12. Kor J Hemost Thromb v.5 Pattern of the activity of fibrinolytic enzyme secreted from Bacillus amyloliquefaciens isolated from Doen-Jang Choi NS;Kim SH
  13. J Ferment Biotech v.84 Characterization of a novel fibrinolytic enzyme from Bacillus sp. KA38 originated from fermented fish Kim HK;Kim GT(et al.) https://doi.org/10.1016/S0922-338X(97)89249-5
  14. Kor J Life Sci v.5 no.4 Fibrinolysis of fermented Kimchi Chung YK;Yang WS;Kang JO;Kong IS;Kim JO
  15. J Ethnopharm v.72 Review on some plants of Indian traditional medicine with antioxidant activity Paolo S;Ester S
  16. Planta Med v.57 Pharmacology of Curcuma longa Ammon HP;Wahl MA
  17. J Agri Food Chem v.40 Antioxidant activity of tropical ginger extracts and analysis of the contained curcuminoids Jitoe VR;Masuda T;Tengah IGP;Suprapta DN;Gara IW;Nakatani N https://doi.org/10.1021/jf00020a008
  18. Mech Ageing Dev v.111 Dietary antioxidants modulation of aging and immune-endothelial cell interaction Meydani M https://doi.org/10.1016/S0047-6374(99)00067-6
  19. Biochem Pharm v.58 Inhibitory effect of Curcumin, a food spice from turmeric, on platelet-activating factor- and Arachidonic acid-me-diated platelet aggregation through inhibition of thromboxane formation and $Ca^2+$ signaling Bukhtiar HS;Zafar N;Shamin AP;Asad R;Hammad M;Sheikh AS;Anwar HG https://doi.org/10.1016/S0006-2952(99)00206-3
  20. Mol Cell Biochem v.166 Hyplipidemic action of curcumin, the active principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats Babu PS;Srinivasan K https://doi.org/10.1023/A:1006819605211
  21. J Nutr v.131 Dietary Curcuminoids prevent high fat dietinduced lipid accumulation in rat liver and epididymal adipose tissue Akira A;Teruo M
  22. Proc Natl Sci Counc v.25 no.2 Mechanisms of cancer chemoprevention by curcumin Lin JK;Lin-shiau SY
  23. J Neurosci v.21 no.21 The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse Giselle PL;Teresa C;Fusheng Y;Walter B;Sally AF;Greg MC
  24. Arzneimittelforschung v.36 Effect of curcumin on platelet aggregation and vascular prostacyclin synthesis Srivastava R;Puri V;Srimal RC;Dhawan BN
  25. Atherosclerosis v.147 Oral administration of a turmeric extract inhibits L이 oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis Ramirez-Tortosa MC;Mesa MD;Aguilera MC;Quiles JL;Baro L;Ramirez-Tortosa CL(et al.) https://doi.org/10.1016/S0021-9150(99)00207-5
  26. Arterioscler Thromb Vasc Biol v.22 Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits Quiles JL;Mesa MD;Ramirez-Tortosa CL;Aguilera CM;Battino M;Gil A(et al.) https://doi.org/10.1161/01.ATV.0000020676.11586.F2
  27. Chin Med J (Engl) v.112 Effects of Curcuma Longa on proliferation of cultured bovine smooth muscle cells and on experssion of low density lipoprotein receptor in cells Zhang W;Liu D;Wo X;Zhang Y;Jin M;Ding Z
  28. Kor J Hemost Thromb v.6 no.1 Anti-thrombotic and anti-hyper-cholesterolemic effect of natural plants extract mixture Kwon ST;Park EH;Paek GY;Jang YS;Hwang JK;Pyun YR;Kim SB;Yed IH;Chung KH
  29. J Nutr v.123 AIN-93 purified diets for laboratory rodents final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent Reeves PG;Nielsen FH;Fahey GC
  30. Clin Chem v.19 Quantitative determination of serum triglycerides by the use of enzymes Bucolo G;David H
  31. Kor J Neur v.15 Effect of triflusal on the platelet aggregation in human whole blood Lee HS;Kang KS;Lee BC;Yu KH