Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Effects of Gamiguibitang on the ovulation in rats

가미귀비탕(加味歸脾湯)이 백서(白鼠)의 배란(排卵)에 미치는 영향(影響)

  • Choe Chang-Min (Department of Gynecology, College of Oriental Medicine, Wonkwang University) ;
  • Hong Gi-Chul (Department of Gynecology, College of Oriental Medicine, Wonkwang University) ;
  • Kim Duck-Nim (Department of Gynecology, College of Oriental Medicine, Wonkwang University) ;
  • Kim Song-Baeg (Department of Gynecology, College of Oriental Medicine, Wonkwang University) ;
  • Yoo Sim-Keun (Department of Gynecology, College of Oriental Medicine, Wonkwang University)
  • 최창민 (원광대학교 부속한방병원 부인과 교실) ;
  • 홍기철 (원광대학교 부속한방병원 부인과 교실) ;
  • 김덕님 (원광대학교 부속한방병원 부인과 교실) ;
  • 김송백 (원광대학교 부속한방병원 부인과 교실) ;
  • 유심근 (원광대학교 부속한방병원 부인과 교실)
  • Published : 2003.12.30
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Abstract

Gamiguibitang(GMGBT) is used in amenorrhea and female infertility caused by ovulation disorder. An attempt was made to evaluate the influences of GMGBT on the serum concentrations of FSH, LH, estradiol(E2) and progesterone, the histological and optical changes of ovary of rats. The results of the study were as follows: 1. Blood FSH level significantly increased in experimental group controlled by four times quantity as compared with control group. 2. Blood LH level increased in experimental group controlled by four times quantity as compared with control group, which showed no efficacy. 3. Blood E2 level increased in experimental group controlled by four times quantity as compared with control group, which showed no efficacy. 4. Blood progesterone level significantly decreased in experimental group controlled by double quantity as compared with control group. 5. In optically observations of ovary, weight of ovary significantly increased in experimental group controlled by double quantity as compared with control group 6. In histological observations of ovary, ovulation significantly increased in experimental group controlled by both double and four times quantity as compared with control group. According to these results, it can be concluded that GMGBT influences the pituitary gland and ovary to increase the ovulation of rats.

Keywords

References

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