Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제29권5호
  • /
  • Pages.315-322
  • /
  • 2003
  • /
  • 2234-7550(pISSN)
  • /
  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
권호 표지

구강내 부위별 편평 상피암종의 생존율에 관한 임상 연구

A CLINICAL STUDY ON THE ANATOMICAL SITE SURVIVAL RATE IN INTRAORAL SQUAMOUS CELL CARCINOMA

  • 김경욱 (단국대학교 치과대학 구강악안면외과학교실) ;
  • 이태희 (단국대학교 치과대학 구강악안면외과학교실)
  • Kim, Kyung-Wook (Departmentment of Oral and Maxillofacial Surgery, School of Dentistry, Dankook University) ;
  • Lee, Tae-Hee (Departmentment of Oral and Maxillofacial Surgery, School of Dentistry, Dankook University)
  • 발행 : 2003.10.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Background : Important factors to determine treatment method and prognosis of oral cancer are anatomical site, tumor size, metastatic lesion, histologic cell differenciation and microvascular invasion. Anatomical site has great effect to oral cancer patient's survival rate because each site's accessibility and lymph node metastasis is different but this factor was't studied much than other factors. Patients and Methods : 228 patients with squamous cell carcinoma of common primary sites(Mandible, Maxilla, Floor of Mouth and Tongue) in oral cavity who were diagnosed in the Korea Cancer Center Hospital from January 1989 to December 1999, were clinically studied and analyzed on survival rate. Results : 1. Survival rates of each anatomical sites were Tongue(36.8%), Mandible(33.3%), Maxilla(28.7%) and Floor of Mouth(24.5%). Survival rates difference between Tongue and Floor of Mouth has significance(p<0.05). 2. Survival rates for early cancer of each site were Maxilla(100%), Mandible(57.1%), Tongue(54.2%) and Floor of Mouth(46.7%). Survival rates difference between Maxilla and Floor of Mouth has significance(p<0.05). 3. Survival rates by surgery method of each site were Maxilla(60.6%), Tongue(56.9%), Mandible(44.8%) and Floor of Mouth(26.3%). Survival rates difference between Maxilla and Floor of Mouth has significance(p<0.05). 4. Survival rates by radiation or chemo method of each site were Floor of Mouth(23.5%), Mandible(20.0%), Maxilla(9.5%), and Tongue(9.1%). Survival rates difference between each site doesn't have significance(p>0.05). 5. In advance stage, Survival rates by single therapy of each site were Tongue(33.6%), Mandible(23.5%), Floor of Mouth(16.7%), Maxilla(0%), and Survival rates difference between Maxilla and Tongue has significance (p<0.05). Survival rates by combination therapy of each site were Mandible(38.1%), Maxilla(30.0%), Floor of mouth(18.2%), Tongue(12.5%), and Survival rates difference between Mandible and Tongue has significance(p<0.05). Conclusion : Survival rate of tongue is higher than the other sites, early detection of oral cancer can increase survival rate at any site and combination therapy is the most effetive method, especially at maxilla.

키워드

참고문헌

  1. Korea Ministry of health and welfare : Assortment of reason for death : 2000, P.8-32.
  2. Sol Silverman Jr MA : Oral Cancer 4th Korean ed. Shinhung Int. : 1999, P. 1-24.
  3. Randolph VL, Vallejo A, Spiro RH : Combination therapy of advanved head and neck cancer, Cancer 41 : 460, 1978.
  4. Bastsakis JG : Tumor of Head and Neck, 2nd ed. William & Wilkins Co : 1979, P.144.
  5. Lee JW, Han YS : Clinical Analysis of intraoral carcinomas. J. of korean Plastic & Recon. Surg. 15 no. 3 : 469-79, 1988.
  6. Arthur Mashberg, Hany Meyers : Anatomical site and size of 222 early asymptomatic oral squamous cell carcinomas : A continuing Prospective of oral cancer Ⅱ. Cancer 37 : 2149-57, 1976. https://doi.org/10.1002/1097-0142(197605)37:5<2149::AID-CNCR2820370502>3.0.CO;2-G
  7. Moore. C : Cigarette smoking and cancer of the mouth, pharynx, and larynx. J.A.M.A 218: 553-8, 1971.
  8. Joe JH, Kim JS : Clinical and Statistical analysis of the oral cancer patients : A statistical analysis of 256 cases J. of Korean Maxillofac. Plastic and Recon. Surg. 20 No 1 : 33-44, 1998.
  9. American Joint Committee on Cancer : Manual for staging of cancer 5th ed : 1997, P.21-52.
  10. Shklar G : Oral Cancer. Saunders Co, 1984, P. 120-9.
  11. Cheng VST, Wang CC, Carcinoma of the paranasal sinuses. A study of sixty-six cases. Cancer 40 :3038-41, 1977. https://doi.org/10.1002/1097-0142(197712)40:6<3038::AID-CNCR2820400641>3.0.CO;2-9
  12. Larheim TA : Carcinoma of maxillary sinuses, palate and maxillary gingiva, occurrence of jaw destruction. Scand J Dent Res 92 : 235-40, 1984.
  13. Kim SG, Yeo HH : Clinical studies on the chemotherapy in advanced oral cancer patients J Oral Maxillofac Surg 19 No 1 : 12-21, 1993.
  14. Shim JW et al : Radiotherapy for oral cavity cancer J of Korean Soc. radiol 11 No. 2 : 267-75, 1993.
  15. Kim KS, Kwon JJ: An overview of treatment trends and present state of oral cancer J of dental academy 31 No 6 : 31-9, 1992.
  16. Mendelson BC, Hodgkinson DJ, Woods Je : Cancer of the oral cavity. Surg Clin North Am : 585-96, 1977.
  17. Nam IW : Management of Oral Cancer, JKDA. 24 No 7 : 569-75, 1986
  18. Evans S J W et al : Prognostic significance of STNMP and Velocity. 49 : 773-6, 1982.
  19. Hauben EI, Weeden S, Pringle J, Van Marck EA, Hogendoorn PC. : Does the histological subtype of high-grade central osteosarcoma influence the response to treatment with chemotherapy and does it affect overall survival? Eur J Cancer Jun 38(9) : 1218-25, 2002.
  20. Na C, Lee YS : Stress and Cancer, J. Psychiatry 19 No 1 : 1-9, 1994.
  21. Parkin D.M. et al : Estimates of the world wide frequency of sixteen major cancer in 1980. Int. J. Cancer, 41: 184-97, 1988. https://doi.org/10.1002/ijc.2910410205
  22. World Health Organization : Application of the international classification of diseases to dentistry and stomatology(ICDDA). Geneva WHO. 2nd ed. : 20-49 1978.
  23. Archer WH et al : A survey of oral carcinoma at the columbia. Presbyterian Medical Center. Am J. Orthodont. & Oral Surg. 32 : 338, 1946.
  24. Pindborg JJ : Oral Cancer and Precancer. Wright : 1980, P. 32-9.
  25. Young JL et al : Cancer incidence and mortality in the United States. 1973-1997. SEER-NIH Publication No 81(2330). National Cancer Institute Monograph No. 57. : 1981.
  26. Min BI et al : Clinical study on the oral squamous cell carcinoma. J Oral Maxillofac Surg 8 : 59-71, 1982.
  27. Kroll SD, Hoffman S : Squamous cell carcinoma of the oral soft tissues : A statistical analysis of 14,523 cases by age, sex and race of patients. JADA. 92 : 571-4, 1976.
  28. Shah, JP : Carcinoma of the oral cavity : Factors affecting treatment failure at the primary site and neck Am J. Surg 132 : 504-7, 1982.
  29. Mustard RA, Rosen IR : Cervical lymphnode involvement in oral cancer. cancer 90 : 978, 1963.
  30. Cho HK : Pathologic study on the incidence of Korean oral cancer. JKDA 22(10) : 887, 1984
  31. Evans SJW, Lagdon JD et al: Prognostic significance of STNMP and Velocity of tumor growth in oral cancer. Cancer 49 : 773, 1982.
  32. Rapidis AD, Langdon JD, Patel MF, Harvey PW : STNMP-a new system for the clinicopathological classification and identification of intraoral carcinoma. Cancer. 39 : 204-29, 1977. https://doi.org/10.1002/1097-0142(197701)39:1<204::AID-CNCR2820390132>3.0.CO;2-9
  33. Silver CE et al : Surgical Treatment of Oral Cavity carcinoma. Head and Neck Surgery Sep/Oct: 57-65 1986.
  34. CC Wahg et al. : Early carcinoma of the oral cavity: A conservative approach with radiation therapy. J Oral Maxillofac Surg 53 : 687-90, 1995. https://doi.org/10.1016/0278-2391(95)90172-8
  35. Victor L Randolph et al : Combination therapy of advanced head and neck cancer. Cancer 41 : 460-467, 1978. https://doi.org/10.1002/1097-0142(197802)41:2<460::AID-CNCR2820410213>3.0.CO;2-9
  36. Kim MJ : Overview of oral cancer at the dentistry. JKDA 28(3) : 244－48, 1990.
  37. Byers RM, EL-Naggar AK, Lee YY : Can We detect or predict the presence of occult nodal metases in patients with squamous carcinoma of the oral tongue? Head Neck 20 : 138, 1980.
  38. Ho CM, Lam KH, Wei WI : Occult lymph node metasis in small oral tongue cancers. Head Neck 14: 359, 1992.
  39. Yuen APW, Wei WI, Wong YM : Elective neck dissection versus observation in the treatment of early oral tongue carcinoma of oral cavity. Am J Surg 168 : 391, 1994.
  40. Jung IW, Cho SK : Review of the literature about oral cancer Cancer. November : 63-9, 1990.
  41. Claire Majoufre et al : Supraomohyoid neck dissection in cancer of the oral cavity Am J Surg 178 : 73-7, 1999.
  42. David E Schuller et al : Preoperative reductive chemotherapy for locally advanced carcinoma of the oral cavity, oropharynx, and hypopharynx. Cancer 51 : 15-9, 1983. https://doi.org/10.1002/1097-0142(19830101)51:1<15::AID-CNCR2820510105>3.0.CO;2-2
  43. Cho BH : Retrospective Study on the Influencing Factors of Survival Rate after Treatments of Oral Cancer. Wonkwang Univ. department of dentistry : 11-4, 2001.
  44. Michael J et al : Postoperative radiation therapy for squamous cell carcinomas of the oral cavity and oropharynx: Impact of therapy on patients with positive surgical margins. Int J Radiation : 17-21, 1992.
  45. Michael J et al : Postoperative Radiotherapy for oral cavity cancer : Impact of anatomic subsite on treatment outcome : 490-8, 1987.
  46. William F Regine et al : Postoperative radiation therapy for primary VS. recurrent squamous cell carcinoma of the head and neck: Results of a comparative analysis. Head & Neck september : 554-9, 1999.
  47. Ryo-ichi Yoshimura et al : Trimodal combination therapy for maxillary sinus carcinoma, Int J Radiation Oncology Biol Phys 35(3) : 656-63, 2002.
  48. Pennachio, J.L. :Combination of Cisplastinum and Bleomycin prior to Surgery and/or Radiotherapy Compared with Radiotherapy Compared with Radiotherapy alone for the treatment of Advanced Squamous Cell Carcinoma of the Head and Neck. Cancer 50 : 2795-2801, 1982. https://doi.org/10.1002/1097-0142(19821215)50:12<2795::AID-CNCR2820501218>3.0.CO;2-0
  49. Discer MJ, Esclamado RM, Sulivan MJ : Indications for the AO plate with a myo cutaneous flap instead of revascularised tissue transfer for mandibular reconstruction. Laryngoscope 103 : 1264-8, 1993.
  50. Whitehurst JO, Droulias CA : Surgical treatment of squamous cell carcinoma of the oral tongue. Arch Otolaryngol 103 : 212, 1997.