Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Effects of Vaccinium koreanum on Rat Lens Aldose Reductase and Platelet Aggregation

산앵도(Vaccinium koreanum) 잎 유래 화합물들의 Aldose Reductase 및 혈전응집에 미치는 효과

  • Joo, Wha-Kyun (Natural Products Research Institute, Seoul National University) ;
  • Jung, Sang-Hoon (Natural Products Research Center, Korea Institute of Science and Technology) ;
  • Cho, Seon-Heang (Gonju National University of Education) ;
  • Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University) ;
  • Lim, Soon-Sung (Silver Biotechnology Research Center, Hallym University)
  • 주화균 (서울대학교 약학대학 천연물과학연구소) ;
  • 정상훈 (한국과학기술연구원 천연물연구센터) ;
  • 조선행 (공주교육대학교 실과교육과) ;
  • 신국현 (서울대학교 약학대학 천연물과학연구소) ;
  • 임순성 (한림대학교 실버생물산업기술연구센터)
  • Published : 2003.12.30
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Abstract

Inhibitory effects of the whole extract and isolated compounds from the leaves of Vaccinium koreanum (Ericaceae) on rat lens aldose reductase (RLAR) and on platelet aggregation were investigated for the prevention or the treatment of chronic diabetic complications. Arbutin, isolated from n-butanol fraction of methanol extract, exhibited a potent inhibitory effects on rat platelet aggregation induced by ADP $(IC_{50}=0.12\;{\mu}M)$ and collagen $(IC_{50}=0.039\;{\mu}M)$ and showed same inhibitory activities with positive control, tetramethylene glutaric acid, on RLAR.

Keywords

References

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