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Effects of Vaccinium koreanum on Rat Lens Aldose Reductase and Platelet Aggregation  

Joo, Wha-Kyun (Natural Products Research Institute, Seoul National University)
Jung, Sang-Hoon (Natural Products Research Center, Korea Institute of Science and Technology)
Cho, Seon-Heang (Gonju National University of Education)
Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University)
Lim, Soon-Sung (Silver Biotechnology Research Center, Hallym University)
Publication Information
Korean Journal of Pharmacognosy / v.34, no.4, 2003 , pp. 314-317 More about this Journal
Abstract
Inhibitory effects of the whole extract and isolated compounds from the leaves of Vaccinium koreanum (Ericaceae) on rat lens aldose reductase (RLAR) and on platelet aggregation were investigated for the prevention or the treatment of chronic diabetic complications. Arbutin, isolated from n-butanol fraction of methanol extract, exhibited a potent inhibitory effects on rat platelet aggregation induced by ADP $(IC_{50}=0.12\;{\mu}M)$ and collagen $(IC_{50}=0.039\;{\mu}M)$ and showed same inhibitory activities with positive control, tetramethylene glutaric acid, on RLAR.
Keywords
Vaccinium koreanum; Ericaceae; Arbutin; Rat lens aldose reductase(RLAR); platelet aggregation;
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