대한두경부종양학회지 (Korean Journal of Head & Neck Oncology)

  • 제18권1호
  • /
  • Pages.41-45
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  • 2002
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  • 1229-5183(pISSN)
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  • 2586-2553(eISSN)
대한두경부종양학회 (The Korean Society for Head and Neck Oncology)
권호 표지

진행성 하인두암에서 선행화학요법과 방사선요법

Neoadjuvant Chemotherapy and Radiotherapy for the Treatment of Advanced Hypopharyngeal Carcinoma

  • 이효정 (서울대학교 의과대학 이비인후과학교실) ;
  • 성명훈 (서울대학교 의과대학 이비인후과학교실) ;
  • 박범정 (한림대학교 의과대학 이비인후과학교실) ;
  • 이명철 (서울대학교 의과대학 이비인후과학교실) ;
  • 심우섭 (서울대학교 의과대학 이비인후과학교실) ;
  • 성원진 (인제대학교 의과대학 상계백병원 이비인후과학교실) ;
  • 노종렬 (서울대학교 의과대학 이비인후과학교실) ;
  • 김광현 (서울대학교 의과대학 이비인후과학교실)
  • Lee Hyo-Jeong (Departmemt of Otolaryngology-Head and Neck Surgery, Seoul National University College of Medicine) ;
  • Sung Myung-Whun (Departmemt of Otolaryngology-Head and Neck Surgery, Seoul National University College of Medicine) ;
  • Park Bum-Jung (Department of Otolaryngology-Head and Neck Surgery, Hallym University College of Medicine) ;
  • Lee Myung-Chul (Departmemt of Otolaryngology-Head and Neck Surgery, Seoul National University College of Medicine) ;
  • Sim Woo-Sub (Departmemt of Otolaryngology-Head and Neck Surgery, Seoul National University College of Medicine) ;
  • Seong Weon-Jin (Department of Otolaryngology-Head and Neck Surgery, Inje University, Sang Gye Paik Hospital) ;
  • Roh Jong-Lyel (Departmemt of Otolaryngology-Head and Neck Surgery, Seoul National University College of Medicine) ;
  • Kim Kwang-Hyun (Departmemt of Otolaryngology-Head and Neck Surgery, Seoul National University College of Medicine)
  • 발행 : 2002.05.01
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초록

Background and Objectives: To evaluate the efficacy of the neoadjuvant chemotherapy and radiation therapy in treatment of patients with advanced hypopharyngeal cancer, which is notorious for its poor prognosis and severe surgical morbidity with functional deficits. Materials and Methods: Medical records and radiologic findings of 107 patients with squamous cell carcinoma of the hypopharynx, Stage III or IV (AJCC, 1997), were retrospectively reviewed. Results: Neoadjuvant chemotherapy followed by radiation therapy showed 74% complete remission (CR) rate. The patients who did not show CR after chemotherapy had a high likelihood of treatment failure, even though they achieved CR following subsequent radiotherapy. Twenty-eight of 57 patients were able to preserve their larynges for more than three years by chemotherapy and radiation. Conclusions: This approach appeared to be as effective as radical surgery with postoperative radiation therapy without comprising of survival. To improve the cure rates, we need to develop better strategies to increase CR rates with chemotherapy and determine the best treatment option for patients who are partially or nonresponsive to chemotherapy.

키워드

참고문헌

  1. Kim KH, Sung MW, Koo JW,et al : Neoadjuvant chemotherapy and radiotherapy for the treatment ofadvanced hypopharyngeal carcinoma. Kor J Otolaryngol. 1997 ; 40 (3) : 429-434
  2. Kim KH, Sung MW, Rhee CS, et al : Neoadjuvant chemotherapy and radiotherapy for the treatment of advanced hypopharyngeal carcinoma. Am J Otolayngol. 1998 ; 19 (1) : 40-44 https://doi.org/10.1016/S0196-0709(98)90064-3
  3. Hoffman HT, Kamell lH, Shah JP, et al : Hypopharyngeal cancer patient care evaluation. Laryngoscope. 1997 ; 107 (8) : 1005-1017 https://doi.org/10.1097/00005537-199708000-00001
  4. Pingree TF, Davis RK, Reichman 0, Derrick L : Treatment of hypopharyngeal carcinoma: a 10-year review of 1362 cases. Laryngoscope. 1987 ; 97 : 901-904
  5. Clayman GL Weber RS : Cancer ofthe hypopharynx and cervical esophagus. In : Myers EN, Suen JY eds Cancer ofthe Head and Neck, edn 3. Philadelphia: W.B. Saunders Co., 1996 : chap 21
  6. Zelefsky MJ, Kraus DH, Pfister DG, et al : Combined chemotherapy and radiotherapy versus surgery and postoperative radiotherapy for advanced hypopharyngeal cancer. Head Neck. 1996 ; 18 : 405-411 https://doi.org/10.1002/(SICI)1097-0347(199609/10)18:5<405::AID-HED3>3.0.CO;2-9
  7. Kraus DH, Zelefsky MI, Brock HA, Huo J, Harrison LB, Shah SP : Combined surgery and radiation therapy for squamous cell carcinoma of the hypopharynx. Otolaryngol Head Neck Surg. 1997 ; 116 : 637-641 https://doi.org/10.1016/S0194-5998(97)70240-7
  8. Choi EC, Lee SY, Koh YW, et al : Treatment results and patterns offailure after surgery for the squamous cell carcinoma ofhypopharynx. Kor J Otolaryngol. 2000 ; 43 : 528-534
  9. Department of Veterans Affairs Laryngeal Cancer Study Group : Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med. 1991 ; 324 : 1685-1690 https://doi.org/10.1056/NEJM199106133242402
  10. Lefebre JL, Chevalier D, Luboinski B, Kirkpatrick N, Collette L, Sahmoud T : Larynx preservation in pyriform sinus cancer : preliminary resurlts ofa European organization for research and treatment of cancer phase III trial. Iournal ofthe national cancer institute. 1996 ; 88 (13) : 890-899 https://doi.org/10.1093/jnci/88.13.890
  11. Shirinian MH, Weber RS, Lippman SM : Larynx preservation by induction chemotherapy plus radiotherapy in locally advanced head and neck cancer. Head and Neck. 1994 ; 16 : 39-44 https://doi.org/10.1002/hed.2880160109