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Neoadjuvant Chemotherapy and Radiotherapy for the Treatment of Advanced Hypopharyngeal Carcinoma  

Lee Hyo-Jeong (Departmemt of Otolaryngology-Head and Neck Surgery, Seoul National University College of Medicine)
Sung Myung-Whun (Departmemt of Otolaryngology-Head and Neck Surgery, Seoul National University College of Medicine)
Park Bum-Jung (Department of Otolaryngology-Head and Neck Surgery, Hallym University College of Medicine)
Lee Myung-Chul (Departmemt of Otolaryngology-Head and Neck Surgery, Seoul National University College of Medicine)
Sim Woo-Sub (Departmemt of Otolaryngology-Head and Neck Surgery, Seoul National University College of Medicine)
Seong Weon-Jin (Department of Otolaryngology-Head and Neck Surgery, Inje University, Sang Gye Paik Hospital)
Roh Jong-Lyel (Departmemt of Otolaryngology-Head and Neck Surgery, Seoul National University College of Medicine)
Kim Kwang-Hyun (Departmemt of Otolaryngology-Head and Neck Surgery, Seoul National University College of Medicine)
Publication Information
Korean Journal of Head & Neck Oncology / v.18, no.1, 2002 , pp. 41-45 More about this Journal
Abstract
Background and Objectives: To evaluate the efficacy of the neoadjuvant chemotherapy and radiation therapy in treatment of patients with advanced hypopharyngeal cancer, which is notorious for its poor prognosis and severe surgical morbidity with functional deficits. Materials and Methods: Medical records and radiologic findings of 107 patients with squamous cell carcinoma of the hypopharynx, Stage III or IV (AJCC, 1997), were retrospectively reviewed. Results: Neoadjuvant chemotherapy followed by radiation therapy showed 74% complete remission (CR) rate. The patients who did not show CR after chemotherapy had a high likelihood of treatment failure, even though they achieved CR following subsequent radiotherapy. Twenty-eight of 57 patients were able to preserve their larynges for more than three years by chemotherapy and radiation. Conclusions: This approach appeared to be as effective as radical surgery with postoperative radiation therapy without comprising of survival. To improve the cure rates, we need to develop better strategies to increase CR rates with chemotherapy and determine the best treatment option for patients who are partially or nonresponsive to chemotherapy.
Keywords
Hypopharyngeal carcinoma; Neoadjuvant chemotherapy; Radiotherapy;
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