Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
권호 표지

Concurrent Chemoradiotherapy versus Radiation Alone in Nasopharyngeal Carcinoma

비인강암에서 동시 항암방사선치료와 방사선치료 단독의 비교 연구

  • Park Jin-Hong (Department of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Chang Hye-Sook (Department of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Kim Sung-Rae (Department of Internal Medicine, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Kim Sang-Yoon (Department of Otorhinolaryngology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Nam Soon-Yuhl (Department of Otorhinolaryngology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Cho Kyung-Ja (Department of Pathology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Kim Jong-Hoon (Department of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Ahn Seung-Do (Department of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Noh Young-Ju (Department of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Choi Eun-Kyung (Department of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Lee Sang-Wook (Department of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center)
  • 박진홍 (울산대학교 의과대학 서울아산병원 방사선종양학과) ;
  • 장혜숙 (울산대학교 의과대학 서울아산병원 방사선종양학과) ;
  • 김성배 (울산대학교 의과대학 서울아산병원 내과) ;
  • 김상윤 (울산대학교 의과대학 서울아산병원 이비인후과) ;
  • 남순열 (울산대학교 의과대학 서울아산병원 이비인후과) ;
  • 조경자 (울산대학교 의과대학 서울아산병원 진단병리과) ;
  • 김종훈 (울산대학교 의과대학 서울아산병원 방사선종양학과) ;
  • 안승도 (울산대학교 의과대학 서울아산병원 방사선종양학과) ;
  • 노영주 (울산대학교 의과대학 서울아산병원 방사선종양학과) ;
  • 최은경 (울산대학교 의과대학 서울아산병원 방사선종양학과) ;
  • 이상욱 (울산대학교 의과대학 서울아산병원 방사선종양학과)
  • Published : 2002.05.01
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Abstract

Objective: To determine the effectiveness and toxicity of chemoradiation therapy in nasopharyngeal carcinoma by comparing with radiation therapy alone. Materials and Methods: Between October 1989 and July 2000, One hundred eleven patients with newly diagnosed and histologically proven nasopharyngeal carcinoma treated in Department of Radiation Oncology, Asan Medical Center were retrospectively reviewed. Forty-five patients were treated with radiation therapy alone (Group I) and 66 patients were treated with radiation therapy and concurrent cisplatin (Group II). Cisplatin was administered once a week, on the first day of each successive week of treatment, starting on day 1 of radiation therapy and given as a intravenous bolus at a dose of $20mg/m^2$ of body-surface area. Radiation therapy was given in doses of 1.8Gy, once a day, 5 days per week with 4MV or 6 MV photons. Initial field was received a total of 60Gy and a primary tumor and enlarged lymph nodes were boosted with an high dose intracavitory brachytherapy and 3D conformal therapy. Results: The complete response rate was 86.7% in Group I, and was 90.9% in Group II. The 5 year overall survival rate for Group I was 60% and for Group II was 45% (p=0.2520). The 5 year disease free survival rate was 52% versus 45%, respectively (p=0.7507). The median follow up was 44 months versus 34 months, respectively. Conclusion: Analysis of the III patients showed no significant difference in disease free survival and overall survival in two treatment group. This retrospective analysis did not demonstrate benefit with concurrent chemoradiation using cisplatin at a dose of $20mg/m^2$ of body-surface area in treatment result than radiation alone.

Keywords

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