한국응용과학기술학회지 (Journal of the Korean Applied Science and Technology)

  • 제19권4호
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  • Pages.281-290
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  • 2002
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  • 1225-9098(pISSN)
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  • 2288-1069(eISSN)
한국응용과학기술학회 (The Korean Society of Applied Science and Technology)
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고상법에 의한 Dermorphin 유사체의 합성과 생물학적 활성에 관한 연구

Synthesis of Dermorphin Analogues by the Solid Phase Method and Biological Activity

  • 한만소 (대진대학교 이공대학 화학과)
  • 발행 : 2002.12.31
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초록

Dermorphin is a hepta peptide(H-Tyr-DAla-Phe-Gly-Tyr-Pro-Ser-$NH_{2}$)with exceptionally potent and long-lasting peripheral and central activity. Dermorphin analogues, dermorphionyl(DMP)-Lys-$NH_{2}$ and DMP-Lys-Lys-$NH_{2}$ have been prepared in order to examine the effect of opiod activity. Dermorphin analogues were synthesized by the solid phase method. The crude peptide was purified by gel filter on a Sephadex LH-20, characterized with HPLC and amino acid analyzer. Analgesic potency was estimated by writhing syndrome method and Randall-Selitto method. As a result, dermorphin analogues have lower potency than that of morphine.

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