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http://dx.doi.org/10.12925/jkocs.2002.19.4.5

Synthesis of Dermorphin Analogues by the Solid Phase Method and Biological Activity  

Han, Man-So (Department of Chemistry, Daejin University)
Publication Information
Journal of the Korean Applied Science and Technology / v.19, no.4, 2002 , pp. 281-290 More about this Journal
Abstract
Dermorphin is a hepta peptide(H-Tyr-DAla-Phe-Gly-Tyr-Pro-Ser-$NH_{2}$)with exceptionally potent and long-lasting peripheral and central activity. Dermorphin analogues, dermorphionyl(DMP)-Lys-$NH_{2}$ and DMP-Lys-Lys-$NH_{2}$ have been prepared in order to examine the effect of opiod activity. Dermorphin analogues were synthesized by the solid phase method. The crude peptide was purified by gel filter on a Sephadex LH-20, characterized with HPLC and amino acid analyzer. Analgesic potency was estimated by writhing syndrome method and Randall-Selitto method. As a result, dermorphin analogues have lower potency than that of morphine.
Keywords
dermorphin; solid phase method; writhing syndrome method; Randall-Selitto method;
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