Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
권호 표지

The effects of calcium aluminate cement according to particle sizes on calvarial bone defects in rats

백서 두개골 결손부에서 입자 크기에 따른 Calcium aluminate cement의 효과

  • Shin, Jung-A (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration, Brain Korea 21 project for Medical Science) ;
  • Yun, Jeong-Ho (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration, Brain Korea 21 project for Medical Science) ;
  • Oh, Seung-Han (Department of Ceramic Engineering, Yonsei University) ;
  • Paik, Jeong-Won (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration, Brain Korea 21 project for Medical Science) ;
  • Choi, Se-Young (Department of Ceramic Engineering, Yonsei University) ;
  • Kim, Chong-Kwan (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration, Brain Korea 21 project for Medical Science) ;
  • Choi, Seong-Ho (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration, Brain Korea 21 project for Medical Science)
  • 신정아 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소, BK21 의과학사업단) ;
  • 윤정호 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소, BK21 의과학사업단) ;
  • 오승한 (연세대학교 공과대학 세라믹 공학과) ;
  • 백정원 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소, BK21 의과학사업단) ;
  • 최세영 (연세대학교 공과대학 세라믹 공학과) ;
  • 김종관 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소, BK21 의과학사업단) ;
  • 최성호 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소, BK21 의과학사업단)
  • Published : 2002.12.31
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Abstract

This present study was carried out to find the effects of calcium aluminate cement($CaO\;{\cdot}\;Al_2O_3$, CAC), which has been developed with bio-compatibility and mechanical properties, in biological environments. Two different particle sizes of CAC - 3.5${\mu}m$ vs. 212${\sim}$250${\mu}m$ which is recommended in periodontal bone grafting procedures-were filled in 8mm calvarial defect in Sprague-Dawley rat. The specimens were examined histologically, especially the bone-cement interface and the response of surrounding tissues. The results are as follows; 1. In the control group, inflammatory cells were observed at 2 weeks. At 8 weeks, periosteum and dura mater were continuously joined together in the defect areas. But in the center of defect area were filled up with the loose connective tissues. 2. In the experimental group l($212{\mu}m{\sim}250{\mu}m$ particle), immature bone was formed and outermost layer was surrounded by osteoid layer at 2 weeks. Osteoblasts were arranged between immature bone and osteoid layer. And, osteoid layer was remained until 8 weeks after surgery. 3. In the experimental group 2, periosteum and dura mater lost its continuity at 2 weeks. Scattering of CAC particles and infiltration of inflammatory cells were observed, which this findings deepened at 8 weeks. The result of this study shows that when calvarial defects in white rats are filled with calcium aluminate cement of 212${\sim}$250${\mu}m$, the materials are to be bio-compatible in growth and healing on surrounding tissues. When further researches are fulfilled, such as direct bone adhesion and bone regeneration ability, it's possible that CAC could be applied to various periodontology fields in the future.

Keywords

References

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