Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Study on 2-thioDMNQ-S160, A Derivative of Shikonin, Antitumor Constituent of Lithospermum Erythrorhizon

자초의 항암성분 수도체 2-thioDMNQ-S160에 관한 연구

  • Song Gyu Yong (Department of Oncology, Graduate School of East- West Medical Science, Kyunghee University) ;
  • Lee Hyo Jung (Department of Oncology, Graduate School of East- West Medical Science, Kyunghee University) ;
  • Khil Jae-Ho (Department of Sports Medicine, Kyunghee University) ;
  • Kim Sung Hoon (Department of Oncology, Graduate School of East- West Medical Science, Kyunghee University)
  • 송규용 (경희대학교 동서의학대학원 동서종양학과) ;
  • 이효정 (경희대학교 동서의학대학원 동서종양학과) ;
  • 길재호 (경희대학교 체육학부 스포츠의학 전공) ;
  • 김성훈 (경희대학교 동서의학대학원 동서종양학과)
  • Published : 2002.06.01
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Abstract

The purpose of this study was to investigate the effect of 2-thioDMNQ-S160, shikonin analogue isolated from Uthospermum Erythrorhizon, on the antitumor activity. In the present study, 2-thioDMNQ-S160 exhibited a significant cytotoxicity against L1210, A549, U937, and 816-BL6 cell lines with IC/sub 50/s of 2.4ug/ml, 2,0ugjml. 4ug/ml and 20 ug/ml, respectively. 2-ThioDMNQ-S160 strongly inhibited adhesion of B16-BL6 cells to gelatin and matrigel coated matrices. Also, 2-ThioDMNQ-S160 exhibited anti-invasive effect of B16-BL6 cells. The T/C% was 123 % in 2-ThioDMNQ-S160 treated group in S-180 bearing ICA mice. These results suggested that 2-thioDMNQ-S160 might be a potent candidate of cancer drug.

Keywords

References

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