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Study on 2-thioDMNQ-S160, A Derivative of Shikonin, Antitumor Constituent of Lithospermum Erythrorhizon  

Song Gyu Yong (Department of Oncology, Graduate School of East- West Medical Science, Kyunghee University)
Lee Hyo Jung (Department of Oncology, Graduate School of East- West Medical Science, Kyunghee University)
Khil Jae-Ho (Department of Sports Medicine, Kyunghee University)
Kim Sung Hoon (Department of Oncology, Graduate School of East- West Medical Science, Kyunghee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.3, 2002 , pp. 542-546 More about this Journal
Abstract
The purpose of this study was to investigate the effect of 2-thioDMNQ-S160, shikonin analogue isolated from Uthospermum Erythrorhizon, on the antitumor activity. In the present study, 2-thioDMNQ-S160 exhibited a significant cytotoxicity against L1210, A549, U937, and 816-BL6 cell lines with IC/sub 50/s of 2.4ug/ml, 2,0ugjml. 4ug/ml and 20 ug/ml, respectively. 2-ThioDMNQ-S160 strongly inhibited adhesion of B16-BL6 cells to gelatin and matrigel coated matrices. Also, 2-ThioDMNQ-S160 exhibited anti-invasive effect of B16-BL6 cells. The T/C% was 123 % in 2-ThioDMNQ-S160 treated group in S-180 bearing ICA mice. These results suggested that 2-thioDMNQ-S160 might be a potent candidate of cancer drug.
Keywords
Uthospermum Erythrorhizon; cytotoxicity; anti-adhesion; invasion assay; TIC %;
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