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Genotoxic Effects of Volatile Organic Compounds in Water  

Jung Kyu Saeng (Graduate School of Public Health, Kyungpook National University)
Lee Chae Yang (Department of Occupational & Environmental Medicine, Kumi CHA Medical Center, College of Medicine Pochon CHA University)
Shin Heuyn Kil (School of Bioscience and Food Technology, Handong University)
Lee Ki Nam (Department of The 3rd Medicine. Professional Graduate School of Oriental Medicine, Wonkwang University)
Jeung Jae Yeal (Department of The 3rd Medicine. Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee Jong Young (Department of Preventive Medicine. School of Medicine, Kyungpook National University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.5, 2002 , pp. 899-904 More about this Journal
Abstract
For determination of the genotoxicity of VOCs(Volatile Organic Compounds) in water, in vitro Comet assay was performed using 3T3 cells. The selected 5 VOCs; Trichloroethylene(TCE), Tetrachloroethylene(PCE), Carbontetrachloride (CteC), Dichloromethane(DCM) and Chlorofrom(Chl) and mixed solvent(Mix), are the test items for drinking water quality. Author analyzed the genotoxicity of these solvents through their tail length (TL) values. Mix, PCE, Chl, TCE in order had cytotoxicity at the highest concentration, and CCl₄ and DCM had no cytotoxic effect. TCE, CCl₄, Chl, PCE, Mix, DCM had genotoxicity, Chl, PCE, Mix had both cytotoxicity and genotoxicity simultaneously, Cytotoxic effect of mixed organic solvents, compared with that of single component, at each concentration, was influenced by the synergistic effect of the interaction of each organic component.
Keywords
Genotoxicity; Volatile Organic Compounds; Comet Assay; Cytotoxicity; Water Quality; 3T3 Cell;
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