DOI QR코드

DOI QR Code

Inhibitory Effects of Ninety Nine Korean Plants on Human Immunodeficiency Virus Type 1 Pretense Activity

  • Park, Jong-Cheol (Department of Oriental Medicine Resources) ;
  • Hur, Jong-Moon (Department of Oriental Medicine Resources) ;
  • Park, Ju-Gwon (Department of Oriental Medicine Resources) ;
  • Hyun, Kyu-Hawn (Department of Resources Plants, Sunchon National University) ;
  • Lee, Kab-Yeon (Sobu Forest Experiment Station, Korea Forest Genetics Research Institute) ;
  • Hirotsugu Miyashiro (Institute of Natural Medicine, Toyama Medical and Pharmaceutical University) ;
  • Masao Hattori (Institute of Natural Medicine, Toyama Medical and Pharmaceutical University)
  • 발행 : 2002.06.01

초록

Ninety nine extracts from Korean plants were screened for their inhibitory activities on human immunodeficiency virus (HIV) type 1 pretense by an HPLC method. The pretense inhibitory activities were determined by incubating the extracts in reaction mixtures containing pretense and substrate (His-Lys-Ala-Arg-Val-Leu-(p-NO$_2$- Phe)-Glu-Ala-Nle-Ser-NH$_2$) to perform proteolytic cleavage reactions. Of the extracts tested, the water extracts of Viburnum awabuki (stem and leaves) and Distylium racemosum (leaves) had the highest pretense inhibitory activities at a concentration of 100ug/mL. Activity-guided fractionation, revealed that the n-butanol fraction of the V. awabuki extract and the ethyl acetate fraction from the D. racemosum extract had the greatest inhibitory activity on HIV-1 pretense.

키워드

참고문헌

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피인용 문헌

  1. Peptide Inhibitor for Human Immunodeficiency Virus Type 1 (HIV-1) Protease from a Thermolysin Hydrolysate of Oyster Proteins vol.13, pp.1, 2010, https://doi.org/10.5657/fas.2010.13.1.084
  2. Inhibitory effects of Korean plant resources on human immunodeficiency virus type 1 protease activity vol.3, pp.1, 2003, https://doi.org/10.3742/OPEM.2003.3.1.001
  3. Isolation of HIV-1 Pretense Inhibiting Peptide from Thermolysin Hydrolysate of Manila Clam Proteins vol.8, pp.2, 2002, https://doi.org/10.3746/jfn.2003.8.2.154