한국환경보건학회지 (Journal of Environmental Health Sciences)

  • 제28권2호
  • /
  • Pages.71-80
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  • 2002
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  • 1738-4087(pISSN)
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  • 2233-8616(eISSN)
한국환경보건학회 (Korean Society of Environmental Health)
권호 표지

흰쥐의 피부조직에 있어서 Cyclohexane의 독성

Effect of Cyclohexane Application to Rat Skin on the Skin Toxicity

  • 전태원 (계명대학교 공중보건학과) ;
  • 조현국 ((재)경북테크노파크 경산대학교 한방생명자원특화센터 효능검증원) ;
  • 윤종국 (경운대학교 안경광학과)
  • 발행 : 2002.06.01
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초록

To evaluate the skin toxicity of topical cyclohexane application (25mg/$\textrm{cm}^2$) was sequentially applied to the rat skin for four days. On the histopathological findings in the light micrographs, neutrophils and engulfed neutrophils are seen, and many cytoplasmic processes were appeared in proliferated layer whereas in the dermis area, increased numbers of fibroblast, accumulation of neutrophil and lipid droplets are demonstrated. On the other hand, applying the cyclohexane to the rat skin led to the remarkable rise of cutaneous xanthine oxidase activity and similar activities of superoxide dismutase and glutathione peroxidase and glutathione content and declined activity of glutathione S-transferase compared with control group. Especially the remarkably decreased activity of aniline hydroxylase (AH) was appeared in skin as little as scarcely determined. Furthermore, the applying the cyclohexane to skin led to the significantly increased activity of hepatic AH and alcohol dehydrogenase. These results indicate that oxygen free radical and intermediate metabolite of cyclohexane may be responsible for structural changes in skin by cyclohexane application to rat skin.

키워드

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