YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Inflammatory Changes in Esophagus and Lower Esophageal Sphincter of HCI-elicited Esophagitis in Cats

HCl에 의한 식도염에서 식도와 하부괄약근의 점막과 근육세포의 인증변화

  • Published : 2002.02.01
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Abstract

The underlying mechanism by which the reflux of gastric juice elicits oesophagitis remaind unclear. To investigate inflammatory response to HCI in tissue of esophagus and lower esophageal sphincter experimental esophagitis was elicited by perfusion of 0.1 N HCI in cats. There was no difference in phospholipase $A_2$ (PLA$_2$) activity of tissue between control and esophagitis. Myeloperoxidase activity in esophagitis was significantly greater than that of control. However histamine content in esophageal mucosa of esophagitis was significantly smaller than that of control. These finding suggest that inflammatory response to HCI in esophagitis is related to changes of myeloperoxidase activity and histamine rather than change of PLA$_2$ activity.

Keywords

References

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