생약학회지 (Korean Journal of Pharmacognosy)

한국생약학회 (The Korean Society of Pharmacognosy)
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쪽파 에탄올 추출물이 과당-유도 고혈압 흰쥐에 미치는 영향

Effects of the Ethanol-extract of Allium wageki on the Fructose-induced Hypertensive Rats

  • 강대길 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 손은진 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 이안숙 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 이윤미 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 윤명호 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 노숙연 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 이호섭 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Kang, Dae-Gill (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Sohn, Eun-Jin (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, An-Sook (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Yun-Mi (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Yin, Ming-Hao (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Noh, Suk-Yun (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Ho-Sub (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 발행 : 2002.12.30
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초록

The effects of the ethanol (EtOH)-extract of Allium wageki were studied on the changes of body weight (BW), systolic blood pressure (SBP), triacylglycerol (TG), cholesterol, and insulin levels in Sprague-Dawley rats in which high fructose feeding elicited hyperinsulinemia, hypertriglyceridemia, and hypertension. SBP and BW were measured for 7 weeks on the fructose diet, fructose/EtOH-extract, vehicle- treated, or vehicle/EtOH-treated rats. The EtOH-extract of Allium wageki blocked the increases of SBP ($119.4{\pm}3.7\;mmHg$ in fructose/EtOH-extract of Allium wageki; $141{\pm}4.3 \;mmHg$ in fructose diet, p<0.01) and BW ($368{\pm}11.4\;g$ in fructose/EtOH-extract of Allium wageki; $402{\pm}15.7\;g$ in fructose diet, p<0.05) by high fructose-diet. The increases of TG, total cholesterol, and insulin levels were also blocked by administration of EtOH-extract of Allium wageki in fructose-induced hypertensive rats. These results suggest that EtOH-extract of Allium wageki has protect effects on the increases of TG, total cholesterol, insulin level, and blood pressure in fructose-induced hypertensive rats.

키워드

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