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Effects of the Ethanol-extract of Allium wageki on the Fructose-induced Hypertensive Rats  

Kang, Dae-Gill (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Sohn, Eun-Jin (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee, An-Sook (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee, Yun-Mi (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Yin, Ming-Hao (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Noh, Suk-Yun (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee, Ho-Sub (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Publication Information
Korean Journal of Pharmacognosy / v.33, no.4, 2002 , pp. 384-388 More about this Journal
Abstract
The effects of the ethanol (EtOH)-extract of Allium wageki were studied on the changes of body weight (BW), systolic blood pressure (SBP), triacylglycerol (TG), cholesterol, and insulin levels in Sprague-Dawley rats in which high fructose feeding elicited hyperinsulinemia, hypertriglyceridemia, and hypertension. SBP and BW were measured for 7 weeks on the fructose diet, fructose/EtOH-extract, vehicle- treated, or vehicle/EtOH-treated rats. The EtOH-extract of Allium wageki blocked the increases of SBP ($119.4{\pm}3.7\;mmHg$ in fructose/EtOH-extract of Allium wageki; $141{\pm}4.3 \;mmHg$ in fructose diet, p<0.01) and BW ($368{\pm}11.4\;g$ in fructose/EtOH-extract of Allium wageki; $402{\pm}15.7\;g$ in fructose diet, p<0.05) by high fructose-diet. The increases of TG, total cholesterol, and insulin levels were also blocked by administration of EtOH-extract of Allium wageki in fructose-induced hypertensive rats. These results suggest that EtOH-extract of Allium wageki has protect effects on the increases of TG, total cholesterol, insulin level, and blood pressure in fructose-induced hypertensive rats.
Keywords
Allium wageki; fructose-induced hypertension; Blood pressure;
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