Environmental Analysis Health and Toxicology

환경독성보건학회 (The Korean Society of Environmental Health and Toxicology)
권호 표지

국내 사용 농약을 대상으로 한 HPLC 방법에 의한 옥탄올/물 분배계수 추정법의 적용성 검토

Applicability of the HPLC Method for the Estimation of Octanol/water Partition Coefficient to Pesticides of Domestic Use

  • 김균 (한국화학연구원 안전성연구센터 환경독성 연구) ;
  • 권진욱 (국립수의과학검역원) ;
  • 김용화 (한국화학연구원 안전성연구센터 환경독성 연구)
  • Kim, Kyun (Environmental Toxicology Research Team.Korea Research Institute of Chemical Technology) ;
  • Kwon, Jin-Wook (National veterinary research & Quarantine service) ;
  • Kim, Yong-Hwa (Environmental Toxicology Research Team.Korea Research Institute of Chemical Technology)
  • 발행 : 2001.12.01
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초록

Octanol/water partition coefficients of 52 chemicals were calculated using RP-HPLC estimation method and predicted by computer program, PCHEM. The result showed relationship between literature values and RP-HPLC observed values (relative coefficient r$^2$＝0.916), but the relationship of PCHEM values with literature values was lower than RP-HPLC value (relative coefficient r$^2$＝0.795). The average difference in partition coefficient between the RP-HPLC method and flask-shaking method was log Kow＝0.54, while the average difference between the values predicted form the computer program and flask- shaking method was log Kow = 0.36 Compared to octanol/water partition coefficients by 3 methods (Flask-shaking, RP-HPLC, computer prediction), the octanol/water partition coefficient values based on the flask-shaking method were very similar to the literature values, while the octanol/water partition coefficient values by RP-HPLC method without to consider the dead time, and computer prediction values did not significantly differ with the literature values.

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