Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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In Vitro Cancer Chemopreventive Activities of Polysaccharides from Soybeans Fermented with Phellinus igniarius or Agrocybe cylindracea

  • Shon, Yun-Hee (Department of Pharmacology, College of Medicine and Intractable Disease Research Center, Dongguk University) ;
  • Nam, Kyung-Soo (Department of Pharmacology, College of Medicine and Intractable Disease Research Center, Dongguk University)
  • Published : 2001.12.01
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Abstract

Chemopreventive activities of polysaccharides from soybeans fermented with either Phellinus igniarius or Agrocybe cylindracea were investigated by measuring the induction of quinone reductase (QR), glutathione S-transferase (GST) activities, and glutathione (GSH) levels in the cell culture along with inhibition of polyamine biosynthesis. The polysaccharides from soybeans fermented with P. igniarius strongly (p<0.005) induced QR activity at all concentrations tested. The extract not only induced GST activity in a dose-dependent manner in the concentration range of 0.1-1.0 mg, but significantly induced GSH revels in cultured Hepa 1c1c7 cells with a maximal 1.4-fold increase at 0.1 mg. The polysaccharides from soybeans fermented with A. cylindracea were effective in inhibiting polyamine metabolism. These results suggest that polysaccharides from soybeans fermented with P. igniarius or A. cylindracea have cancer chemopreventive activities in in vitro models and, therefore, could be considered as potential agents for cancer chemoprevention.

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References

  1. Cancer Res. v.57 Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces phase Ⅱ drug-metabolizing enzymes Gerhauser, C.;M. You;J. Liu;R. M. Moriarty;M. Hawthorne;R. G. Mehta;R. C. Moon;J. M. Pezzuto
  2. Anal. Biochem. v.106 Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine Griffith, O. W.
  3. Anticancer Res. v.15 Chemoprevention of chemically-induced mammary carcinogenesis by indle-3-carbinol Grubbs, C.;V. E. Steele;T. Caseblot;M. M. Juliana;I. Eto;L. M. Whitaker;K. H. Dragney;G. L. Kelloff;R. L. Lubet
  4. J. Biol. Chem. v.249 Glutathione S-transferases: The first enzymatic step in mercapturic acid formation Habig, W. H.;M. J. Pabst;W. B. Jakoby
  5. Biotech. Lett. v.22 Antimutagenic activity of soybeans fermented with basidiomycetes in Ames/Salmonella test Kim, S. Y.;Y. H. Shon;J. S. Lee;C. H. Kim;K. S. Nam
  6. J. Microbiol. Biotechnol. v.9 Anti-complementary properties of polysaccharides isolated from fruit bodies of mushroom Pleurotus ostreatus Kweon, M. H.;H. Jang;W. J. Lim;H. I. Chang;C. W. Kim;H. C. Yang;H. J. Hwang;H. C. Sung
  7. J. Microbiol. Biotechnol. v.10 Characterization of two glucans activating an alternative complement pathway from the fruiting bodies of mushroom Pleurotus ostreatus Kweon, M. H.;W. J. Lim;H. C. Yang;H. C. Sung
  8. Cancer Res. v.42 Isolation and identification of kahweol palmitate and cafestal palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in mouse Lam, L. K. T.;V. L. Sparnins;L. W. Wattenberg
  9. J. Microbiol. Biotechnol. v.7 Immunostimulating activity of polysaccharides from mycelia of Phellinus linteus grown under different culture conditions Lee, J. H.;S. M. Cho;H. M. Kiom;N. D. Hong;I. D. Yoo
  10. Annu. Rev. Biochem. v.52 Glutathione Meister, A.;M. Anderson
  11. Functions of Glutathione: Biochemical, Physiological, and Clinical Aspects Interaction of glutathione with reactive intermediates Molders, P.;B. Jernestrom;Larson, A.(ed.);S. Orrenius(ed.);A. Holgren(ed.);B. Mannervik(ed.)
  12. Biochem. J. v.234 Recent advances in the biochemistry of polyamines in eukaryotes Pegg, A. E.
  13. Anticancer Res. v.63 Interference with polyamine buisynthesis and/or function by analogs of polyamines or methionine as a potential anticancer chemotherapeutic strategy Porter, C. W.;J. R. Sufrin
  14. Anal. Biochem. v.169 Direct measurement of NAD(P)H:Quinone reductase from cells cultured in microiter wells: A screening assay for anticarcinogenic enzyme inducers Prochaska, H. J.;A. B. Santamaria
  15. Carcinogenesis v.12 Inhibition by dietery oltipraz of experimental intestinal carcinogenesis induced by azoxymethane in male F344 rats Rao, C. V.;K. Tokomo;G. Kelloff;B. S. Reddy
  16. Cancer Res. v.50 Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antiinflammatory drug with D,L-α-difluoromethylornithine, an ornithine decarboxylase inhibitor, in diet Reddy, B. S.;J. Nayini;K. Tokumo;J. Rigotty;E. Zang;G. Kelloff
  17. Cancer Res. v.51 Protection aganist alatoxin B₁induced hepatocarcingenesis in F344 rats by 5-(2-pyraziny)-4-methyl-1,2-dithiol-3-thione(oltipraz): Predictive role for molecular dosimetry Reobuck, B. D.;Y. L. Liu;A. E. Rogers;J. D. Groopman;T. W. Kensler
  18. J. Microbiol. Biotechnol. v.9 Antimutagenic potential of Phellinus igniarius Shon, Y. H.;J. S. Lee;H. W. Lee;K. S. Nam
  19. J. Ethnopharm v.77 Antimutagenicity and induction of anticarcinogenic phase potential of Phellinus igniariusⅡ enzymes by basidiomycetes Shon, Y. H.;K. S. Nam
  20. J. Microbiol. Biotechnol. v.11 Antimutagenic effect of polysaccharides extracted from soybeans fermented with basidiomycetes on 2-amino-3,8-dimethylimidazo[4,5,-f]quinoxaline (MeIQx) Shon, Y. H.;S. Y. Kim;J. S. Lee;J. K. Lim;K. S. Nam
  21. J. Microbiol. Biotechnol. v.10 Enhancement of phase and Ⅱ antioxidant enzymes by soybeans fermented with basidiomycetes in mice Shon, Y. H.;S. Y. Kim;J. S. Lee;K. S. Nam
  22. Environ. Health Prespet. v.50 Overview of tumor promotion in animals Slaga, T. J.
  23. J. Microbiol. Biotechnol. v.8 Paclitaxel(Taxol): From nut to drug Sohn, H.;M. R. Okos
  24. J. Microbiol. Biotechnol. v.8 The anti-complementary activity of exopolyners produced from subnerged mycelial cultures of higher fungi with particular reference to Cordyceps militaris Song, C. H.;Y. J. Jeon;B. K. Yang;K. S. Ra;J. M. Sung
  25. Carcinogenesis v.9 Effects of organosulfur compounds from garlic and onions on benzo[a]pyrene-induced neoplasis and glutathione S-transferase activity in the mouse Sparnins, V. L.;G. Barany;L. W. Wattenberg
  26. Toxicol. Lett. (Amst.) v.82 Chemprotection against cnacer by phase Ⅱ enzyme induction Talalay, P.;J. W. Fahey;W. D. Holtzclaw;T. Prestrea;Y. Zhang
  27. Cancer Res. v.53 Chemprevention of oral carcinogenesis by D,L-α-difluoromethylornithine, an ornithine decarboxylase inhibitor: Dose-dependent reduction in 4-nitroquinoline 1-oxide-induced tongue neplasms in rats Tanaka, T.;T. Kojima;A. Har;H. Sawada;H. Mori
  28. J. Microbiol. Biotechnol. v.10 Production of exopolymers by submerged mycelial culture of Cordyceps militaris and its hypolipidemic effect Yang, B. K.;J. Y. Ha;S. C. Jeong;S. Das;J. W. Yun;Y. S. Lee;J. W. Choi;C. H. Song
  29. Cancer Res. v.54 Anticarcinogenic activities of organic isothiocyanates: Chemistry and mechnisms Zhang, Y.;P. Talalay
  30. Proc. Natl. Acad. Sci. USA v.91 Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates Zhang, Y.;T. W. Kensler;C. G. Cho;G. H. Posner;P. Talalay