Studies on the Effect and Mechanism of Geupoongjibo-dan's Relaxation on a Blood Vessel

거풍지보단(祛風至寶丹)의 혈관이완 효능과 기전에 관한 연구

  • Kim, Dong-Eun (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Park, Dong-Wan (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Jeong, Sung-Hyun (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Shin, Gil-Cho (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Lee, Won-Chul (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Han, Sung-Ho (Department of Internal Medicine, College of Oriental Medicine, Dongguk University)
  • 김동은 (동국대학교 한의과대학 내과학교실) ;
  • 박동완 (동국대학교 한의과대학 내과학교실) ;
  • 정승현 (동국대학교 한의과대학 내과학교실) ;
  • 신길조 (동국대학교 한의과대학 내과학교실) ;
  • 이원철 (동국대학교 한의과대학 내과학교실) ;
  • 한성호 (동국대학교 한의과대학 내과학교실)
  • Published : 2001.06.30

Abstract

Objectives : This study was conducted to evaluate the effect and mechanism of Geupoongjibo-dan's relaxation of the tension of the blood vessel caused by Phenylephrine and KCI. Methods : In order to study the effect of Geupoongjibo-dan's relaxation of the blood vessel tension, Geupoongjibo-dan extract was infused into Phenylephrine and KCI-induced contracted rabbit aorta strips. To analyze the mechanism of Geupoongjibo-dan's effect on the blood vessel, Geupoongjibo-dan extract infused into Phenylephrine and KCI-induced contracted strips induced by agonists after treatment of N${\omega}$-nitro-L-arginine, Methylene Blue. Results : 1. Geupoongjibo-dan was very effective in relaxing the blood vessels contracted by Phenylephrine. 2. Geupoongjibo-dan was effective against Phenylephrine, than against KCI. 3. Geupoongjibo-dan's more relaxation effect on a blood vessel was terminated by N${\omega}$-nitro-L-arginine and methylene treatment. Conclusion : THis study showed that Geupoongjibo-dan's relaxation effect on a blood vessel is irrelevant to ${\alpha}$-adrenalin receptor, and it relaxes contracted vessels through cGMP channel.

Keywords

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