The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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The Effects of Samwha-tang Extracts on Reversible Forebrain Ischemia Experimentally Induced from the Occlusion of Middle Cerebral Artery

삼화탕(三化湯)이 중간대뇌동맥 결찰로 유발된 뇌허혈에 미치는 영향

  • Jeong, Sung-Hyun (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Park, In-Sick (Department of Anatomy, College of Oriental Medicine, Dongguk University) ;
  • Shin, Gil-Cho (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Lee, Won-Chul (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Kim, Dong-Eun (Department of Internal Medicine, College of Oriental Medicine, Dongguk University)
  • 정승현 (동국대학교 한의과대학 내과학교실) ;
  • 박인식 (동국대학교 한의과대학 해부학교실) ;
  • 신길조 (동국대학교 한의과대학 내과학교실) ;
  • 이원철 (동국대학교 한의과대학 내과학교실) ;
  • 김동은 (동국대학교 한의과대학 내과학교실)
  • Published : 2001.06.30
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Abstract

The purpose of this investigation is to evaluate the effects of Samwha-tang(三化湯) Extracts on reversible forebrain ischemia experimentally induced from the occlusion of middle cerebral artery. The volume of cerebral ischemia, the volume of cerebral edema, and the change of pyramidal neuron of the CA1 area in hippocampus through light microscopy were investigated. we obtained the following results. The volume of the control group, which had ischemic damage was 21%, and the volume of the sample group, which had ischemic damage, was 16%. The ratio of the volume of the right/left hemisphere was 117.2 in the control group, and 108.8 in the sample group. Also, the light microscopy revealed that the pyramidal cells of CA1 area in hippocampus had many damages like changes into discontinuous and unsystematic forms. But, in the sample group, the cells were less damaged compared with the control group.

Keywords

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