The Journal of Korean Society of Virology (대한바이러스학회지)

The Korean Society of Virology (대한바이러스학회)
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Study on Variation of Endemic Mumps Viruses in Korea

한국에서 분리된 유행성이하선염 바이러스 변이에 관한 연구

  • Min, Kyung-Il (Division of Viral Products, Biologics Evaluation Department, Korea Food and Drug Administration) ;
  • Kim, Do-Keun (Division of Viral Products, Biologics Evaluation Department, Korea Food and Drug Administration) ;
  • Cho, Soo-Yeul (Division of Viral Products, Biologics Evaluation Department, Korea Food and Drug Administration) ;
  • Ahn, Kwang-Soo (Division of Specific Toxicology, Toxicology Department, National Institute of Toxicological Research) ;
  • Min, Bok-Soon (Division of Viral Products, Biologics Evaluation Department, Korea Food and Drug Administration) ;
  • Kim, Byoung-Guk (Division of Viral Products, Biologics Evaluation Department, Korea Food and Drug Administration) ;
  • Ban, Sang-Ja (Division of Bacterial Products, Biologics Evaluation Department, Korea Food and Drug Administration) ;
  • Hur, Sook-Jin (Division of Blood Products, Biologics Evaluation Department, Korea Food and Drug Administration) ;
  • Park, Sue-Nie (Division of Viral Products, Biologics Evaluation Department, Korea Food and Drug Administration) ;
  • Lee, Kil-Ung (Division of Viral Products, Biologics Evaluation Department, Korea Food and Drug Administration)
  • 민경일 (식품의약품안정청 생물학평가부 바이러스제제과) ;
  • 김도근 (식품의약품안정청 생물학평가부 바이러스제제과) ;
  • 조수열 (식품의약품안정청 생물학평가부 바이러스제제과) ;
  • 안광수 (국립독성연구소 독성부 특수독성과) ;
  • 민복순 (식품의약품안정청 생물학평가부 바이러스제제과) ;
  • 김병국 (식품의약품안정청 생물학평가부 바이러스제제과) ;
  • 반상자 (식품의약품안정청 생물학평가부 세균제제과) ;
  • 허숙진 (식품의약품안정청 생물학평가부 혈액제제과) ;
  • 박순희 (식품의약품안정청 생물학평가부 바이러스제제과) ;
  • 이길웅 (식품의약품안정청 생물학평가부 바이러스제제과)
  • Published : 2000.06.30
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Abstract

We had isolated 8 viruses from 91 specimen collected at southwest Cheju Province during early spring 1998 and 2 viruses from 9 specimen collected at Chung Nam Province during early spring 1999. To perform cross-reactivity among 4 mumps vaccine strains and 10 wild-type mumps viruse isolates, we immunized mice and took antisera against each virus. There were no antibody titer differences by indirect immunofluorescence assay (IFA), but most isolated mumps viruses showed a little cross-reactivities with Jeryl Lynn and Rubini strains. It has shown similar result by haemagglutination-inhibition (HAI) test. These results show that 4 mumps strains used as vaccine have the protection ability against endemic wild-type mumps viruses. Also the SH gene analysis was performed to identify genotypes. Most isolated mumps viruses belonged to genotype D. These results indicate that endemic mumps viruses in Korea are different to ones isolated in Japan and China.

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