Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Anti-hypertensive Effects of Pini Folium and Leonuri Herba Extract on Spontaneously Hypertensive Rat (SHR)

SHR(Spontaneously Hypertensive Rat)를 이용한 송엽, 익모초 추출물의 항고협알 작용

  • 박건구 (아산생명과학연구소 분자유전연구실) ;
  • 류재원 (아산생명과학연구소 분자유전연구실) ;
  • 최은경 (울산대학교 의과대학) ;
  • 노환성 (울산대학교 의과대학)
  • Published : 2000.03.01
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Abstract

The aim of this study was to investigate a potential effect of treatment of spontaneously hypertensive rats (SHR) with Pini Folium or Leonuri Herba extracts. Male SHR were treated with extracts for 2 or 4 weeks starting at 13 weeks of age. We found that oral treatment with the methanol extract from Pini Folium or Leonuri Herba (1g/Kg/day) significantly decreased mean blood pressure to 85.4% and 78.6% respectively in compare with untreated control SHR. Treatment with the extract from Pini Folium for 4 weeks during hypertension development phase (starting 9 weeks of age) resulted in a partial prevention of hypertension development. There were no significant differences for body weight between untreated and Pini Folium treated SHR.

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