Animal Models of Alzheimer's Dementia

알쯔하이머 치매의 동물모형

  • Woo, Sung-Il (Department of Psychiatry, School of Medicine, Gyeongsang National University, Gyeongsang Institute for Neuroscience)
  • 우성일 (경상대학교 의과대학 정신과학교실, 경상대학교 신경과학연구소)
  • Published : 1999.12.25

Abstract

Transgenic mice models of Alzheimer's disease were produced by overexpressing APP(amyloid precursor protein) mutant and presenilin mutant genes using the promotors that induced neuronal expression. The neuropathologies, electrophysiological changes and behavioral changes that were demonstrated in these transgenic mice models were amyloid changes, gliotic changes, A-beta increases, deficit in LTP(long-term potentiation) and behavioral changes. Some or all of the above changes were found in each transgenic mice model. These models generally showed amyloid neuropathology but they usually lacked the neurofibrillary tangles. So, they can be regarded as partial models of Alzheimer's disease. The development of them is undoubtedly the great progress toward future research.

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Acknowledgement

Supported by : 경상대학교병원