대한화장품학회지 (Journal of the Society of Cosmetic Scientists of Korea)

  • 제25권1호
  • /
  • Pages.120-136
  • /
  • 1999
  • /
  • 1226-2587(pISSN)
  • /
  • 2288-9507(eISSN)
대한화장품학회 (Society of Cosmetic Scientists of Korea)
권호 표지

$\beta-cyclodextrin$ 및 유도체의 포접체 형성에 의한 LG 106W의 유용성 및 안정성 개선에 관한 연구

Improvement in availability and stability of to 106w by inclusion with $\beta-cyclodextrin$ and its derivatives

  • 정성훈 (LG 생활건강 화장품연구소) ;
  • 이천구 (LG 생활건강 화장품연구소) ;
  • 조완구 (LG 생활건강 화장품연구소) ;
  • 강세훈 (LG 생활건강 화장품연구소)
  • 발행 : 1999.03.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

A newly synthesized polyhydroxy aromatic compound(LG 106w) has good skin lightening effect. Inclusion complexation of LG 106w with $\beta$-cyclodextrin and its hydroxypropyl and dimethyl derivatives was studied by the solubility method, scanning electron microscopy and differential thermal analysis. A relationship between host and guest was clearly reflected in the magnitude of the stability constant(DM-$\beta$> HP-$\beta$>$\beta$ -cyclodextrin). Formulation problems, which resulted from its very low solubility in aqueous solution, were resolved by the inclusion formation. LG 106W from inclusions is much more water-soluble than pure one. The improvement of pH and temperature stability correlated with the increased solubility was also observed. Inclusion complex of LG 106w had similar activity to pure LG 106w on the inhibition of melanin synthesis in B-16 melanoma cell but showed lower irritation on cultured cell test in vitro. According to the results, cyclodextrins might be one of the reliable candidates for improving the availability of LG 106w.

키워드

참고문헌

  1. Cyclodextrins and Their Inclusion Complexes Szejtli, J.
  2. Cyclodextrins and Their Industrial Uses Dunchene, D.
  3. Angew. Chem. Int. Ed. Engl. v.19 Cyclodextrins Inclusion compounds in research and industry Saenger, W.
  4. Cyclodextrin Technology Szejtli, J.
  5. Yakugaku Zasshi v.101 Pharmaceutical applications of cyclodextrin complexations Uekama, K.
  6. 3rd ASCS Scientific Conference Development of whitening agents by synthesis of polyhydroxy aromatic compounds Lee, H.H.
  7. J. Am. Pharm. Assoc. Sci. Edn. v.43 Investigation of some complexes formed in solution by caffeine IV: Interaction between caffeine and sulfathiazole, sufadiazine, p-aminobenzoic acid, benzocaine, phenobarbital and barbital Higuchi, T.;Lach, J.L.
  8. Adv. Anal. Chem. Instr. v.4 Phase-solubility techniques Higuchi, T.;Connors, K.A.
  9. J. Inc. Phenom. v.6 Enhanced dissolution and oral bioavailability of α-tocophery1 esters by dimethy1-β-cyclodextrin complexation Uekama, K.
  10. Pharmazie v.37 The β-cyclodextrin inclusion complex of menadione(Vitamin K₃) Szejtli, J.;Bolla-Pusztai, E.;Kajatar, M.
  11. Pharmazie Preparation, Properies and biological activity of β-cyclodextrin inclusion complex of menadione Szejtli, J.;Bolla-Pusztai, E.;Tardy-Lengyel, M.;Szabo, P.;Ferenczy, T.
  12. Cyclodextrin inclusion compound of 2-n-octy1-4-octy1-isothiazoline-3-one useful as a fungicide having long-lasting effect Takeda Chemical Industries Limited
  13. Nonirritating Cosmetics Sunstar Inc.
  14. Dentifrice Composition without lowering the potency Sun Star Dentifrice
  15. Toothpaste compositions contatining sucrose fatty ester foaming agents and cyclodextrin to prevent decrease in foaming ability without inactivating enzymes present Sun Star Dentifrice;Daiichi Kogyo Seiya;Hashimoto, S.;Inoue, K.;Watanabe, T.
  16. CRC Crit. Rev. Ther. Drug Carrier Systems v.3 Cyclodextrins in drug carrier systems Uekama, K.;Otagiri, M.